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Number of items: 85.

A

Al-Marzouqi, I and Levy, MS and Lye, GJ (2004) Capture and purification of plasmid DNA gene therapy vectors from cell lysates using countercurrent chromatography. In: (Proceedings) 3rd International Conference on Countercurrent Chromatography. : Tokyo, Japan.

B

Baganz, F (2004) Towards the scale down of mammalian cell culture processes. In: (Proceedings) Cell culture and Upstream Processing. : Berlin, Germany..

Baganz, F and Jacques, C and Ushio, M and Zhou, Y and Ward, JM and Leadley, P (2004) Examining the effect of genetic modifications in primary metabolism on polyketide production by saccharopolyspora erythraea. In: (Proceedings) Metabolic Eng. (pp. 19 - 23). : Lake Tahoe, USA.

Bamford, VA and Kolade, OO and Osbourn, AE and Hemmings, AM (2004) Purification, crystallization and preliminary X-ray diffraction analysis of a fungal saponin-detoxifying enzyme. ACTA CRYSTALLOGR D , 60 1331 - 1333. 10.1107/S0907444904011850.

Booth, AJ and Ngiam, SH and Lye, GJ (2004) Antibiotic purification from fermentation broths by counter-current chromatography: analysis of product purity and yield trade-offs. BIOPROC BIOSYST ENG , 27 (1) 51 - 61. 10.1007/s00449-004-0380-2.

Booth, AJ and Ngiam, SH and Lye, GJ (2004) Antibiotic purification from fermentation broths by counter-current chromatography: analysis of product purity and yield trade-offs – erythromycin-A production and downstream processing from sacchropolyspora erythraea. Bioprocess and Biosystems Engineering , 1 (27) 51 - 61.

Boychyn, M and Yim, SSS and Bulmer, M and More, J and Bracewell, DG and Hoare, M (2004) Performance prediction of industrial centrifuges using scale-down models. BIOPROC BIOSYST ENG , 26 (6) 385 - 391. 10.1007/s00449-003-0328-y.

Bracewell, DG (2004) Supporting the design and operation of chromatographic sequences through new graphical tools. In: (Proceedings) The 227th ACS National Meeting. : Anaheim, CA.

Bracewell, DG and Brown, RA and Hoare, M (2004) Addressing a whole bioprocess in real-time using an optical biosensor-formation, recovery and purification of antibody fragments from a recombinant E-coli host. BIOPROC BIOSYST ENG , 26 (4) 271 - 282. 10.1007/s00449-004-0359-z.

Bracewell, DG and Hoare, M (2004) Enhanced bioprocess development and operation by use of real-time biosensor monitoring. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (pp. U128 - U128). AMER CHEMICAL SOC

C

Chan, and S, and Sorensen, and E, and Titchener-Hooker, and N, (2004) A systematic procedure for model selection and model parameter estimation for chromatographic processes. In: (Proceedings) AIChE 2004 Annual meeting.

Chan, S and Sørensen, E and Titchener-Hooker, N and Bracewell, D (2004) A systematic procedure for model selection and model parameter estimation for chromatographic processes. In: (Proceedings) Proc. of AIChE Annual Meeting, Austin. (pp. Paper 482g - ?).

Cohen-Gonsaud, M and Keep, NH and Davies, AP and Ward, J and Henderson, B and Labesse, G (2004) Resuscitation-promoting factors possess a lysozyme-like domain. TRENDS BIOCHEM SCI , 29 (1) 7 - 10. 10.1016/j.tibs.2003.10.009.

Cooke, JR and McKie, EA and Ward, JM and Keshavarz-Moore, E (2004) Impact of intrinsic DNA structure on processing of plasmids for gene therapy and DNA vaccines. Journal of Biotechnology , 114 (3) 239 - 254. 10.1016/j.jbiotec.2004.06.011.

Cooke, JR and McKie, EA and Ward, JM and Keshavarz-Moore, E (2004) Impact of intrinsic DNA structure on processing of plasmids for gene therapy and DNA vaccines. J BIOTECHNOL , 114 (3) 239 - 254. 10.1016/j.jbiotech.2004.06.011.

Cooke, JR and McKie, EA and Ward, JM and Keshavarz-Moore, E (2004) Impact of intrinsic DNA structure on processing of plasmids for gene therapy and DNA vaccines. J Biotechnol , 114 (3) 239 - 254. 10.1016/j.jbiotec.2004.06.011.

D

Dalby, PA (2004) Expanding the Repertoire of Organic Synthesis by Transketolase. In: (Proceedings) Royal Society of Chemistry Symposium on Achievements and Challenges in Biotransformation.

Dey-Choudhury, A and Levy, MS and Lye, GJ and Gyepi-Gabrah, I and Savory, P (2004) Capture and purification of plasmid DNA from clarified alkaline lysates using anion exchange chromatographic membranes. In: (Proceedings) 9th International Symposium on BioChromatography. : Bordeaux, France.

Dey-Choudhury, A and Levy, MS and Lye, GJ and Gyepi-Garbrah, I and Savory, P (2004) Capture and purification of plasmid DNA from clarified alkaline lysates using anion exchange chromatographic membranes. In: (Proceedings) IChemE Fluid Separation Processes Research Event. : Imperial College, London.

E

Elmahdi, I and Baganz, F and Dixon, K and Harrop, T and Sugden, D and Zhang, H and Lye, GJ (2004) Automated scale down approaches for rapid fermentation process development. In: (Proceedings) Biotechnology 2004, 12th International Biotechnology Symposium. : Santiago, Chile.

Esponda-Aguilar, P and Gbewonyo, K and Huerta-Ochoa, S and Hussain, W and Lye, GJ and Roberts, NJ and Seago, A (2004) Process design for the synthesis of pharmaceutical intermediates in ionic liquids using whole cell and isolated enzyme biocatalysts. In: (Proceedings) 5th European Symposium of Biochemical Engineering Science. : Stuttgart, Germany.

F

Fish, SJ and Lye, GJ and Woodley, JM (2004) ). Investigation of the effect of Water Immiscible Liquids and Solid Particles on Oxygen Transfer Rate in Stirred Tank Bioreactor. In: (Proceedings) ESBES 5. : Stuttgard, Germany.

G

Gardner, PJ and Willoughby, N and Hjorth, R and Lacki, K and Titchener-Hooker, NJ (2004) Use of dimensionless residence time to study variations in breakthrough behaviour in expanded beds formed from varied particle size distributions. BIOTECHNOL BIOENG , 87 (3) 347 - 353. 10.1002/bit.20119.

H

Harrison, J and Keshavarz-Moore, E (2004) Development of a generic process for the isolation of antibody fragments. In: (Proceedings) Proceedings of Institution of Chemical Engineers. IChemE Research Event. : London.

Hernandez, D and Addou, S and Lee, D and Orengo, C and Shephard, EA and Phillips, IR (2004) Trimethylaminuria and a human FMO3 mutation database. Human Mutation , 22 (3) 209 - 213.

Hernandez, D and Janmohamed, A and Chandan, P and Phillips, IR and Shephard, EA (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. PHARMACOGENETICS , 14 (2) 117 - 130. 10.1097/01.fpc.0000054152.92680.ea.

Hernandez, D and Janmohamed, A and Chandan, P and Phillips, IR and Shephard, EA (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Pharmacogenetics , 14 (2) 117 - 130.

Hernandez, D. and Janmohamed, A. and Chandan, P. and Phillips, I.R. and Shephard, E.A. (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse. Pharmacogenetics , 14 (2) pp. 117-130. 10.1097/00008571-200402000-00006.

Hoare, M (2004) Speeding biopharmaceutical discoveries to available medicines. In: (Proceedings) Recombinant Bioprocessing meeting, Biochemical Engineering Research Network (BERN). : Heriot Walt University, Edinburgh.

Hoare, M (2004) Speeding biopharmaceuticals products to market. In: (Proceedings) 3rd annual biological production forum - Biomanufacturing. : Edinburgh.

Hodgson, BJ and Taylor, CN and Ushio, M and Leigh, JR and Kalganova, T and Baganz, F (2004) Intelligent modelling of bioprocesses: a comparison of structured and unstructured approaches. BIOPROCESS AND BIOSYSTEMS ENGINEERING , 26 (6) 353 - 359. 10.1007/s00449-004-0382-0.

J

Janmohamed, A and Hernandez, D and Phillips, IR and Shephard, EA (2004) Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). BIOCHEM PHARMACOL , 68 (1) 73 - 83. 10.1016/j.bcp.2004.02.036.

K

Kennedy, DO and Booth, A and Chan, G and Kong, S and Bracewell, DG and Willoughby, N and Relton, JM and Levy, MS (2004) Plasmid DNA for gene therapy and DNA vaccination: novel scale-down techniques for bioprocess operations. In: (Proceedings) Biotechnology 2004.

Keshavarz-Moore, E (2004) Upstream bioprocess engineering challenges in gene therapy and vaccination. In: (Proceedings) EuroLabCours, Gene Therapy Programme. : Evry.

King, JMP and Griffiths, P and Zhou, YH and Titchener-Hooker, NJ (2004) Visualising bioprocesses using '3D-Windows of Operation'. J CHEM TECHNOL BIOT , 79 (5) 518 - 525. 10.1002/jctb.1015.

King, JMP and Zhou, YH and Titchener-Hooker, NJ (2004) Quantification of robustness for bioprocess validation: A chromatography case-study using Monte-Carlo simulation. In: (Proceedings) 9th International Symposium on Computer Applications in Biotechnology (CAB9).

Krabben, P and Jaques, C and Akinrinsola, IA and Ushio, M and Baganz, FAW and J, (2004) Connecting genome to process. Metabolic engineering, genome analysis and product flux. In: (Proceedings) Metabolic Engineering V.

L

Law, HEM and Lewis, D and Woodley, JM (2004) Characterisation of a reaction to produce a Biodegradable Chelant by a Carbon-Nitrogen Lyase. In: (Proceedings) Symposium on Biochemical Engineering Science 5 (ESBES-5). : Stuttgart, Germany.

Lee, YH and Kolade, OO and Arvidson, DN and He, SY (2004) Identification of HrpA mutants that block type III secretion in Pseudomonas syringae pv. tomato DC3000. PHYTOPATHOLOGY , 94 (6) S59 - S59.

Lim, AC and Zhou, Y and Washbrook, J and Titchener-Hooker, NJ and Farid, S (2004) A decisional-support tool to model the impact of regulatory compliance activities in the biomanufacturing industry. Computers and Chemical Engineering , 28 (5) 727 - 735.

Lim, AC and Zhou, Y and Washbrook, J and Titchener-Hooker, NJ and Farid, SS (2004) A decisional-support tool to model the impact of regulatory compliance activities in the biomanufacturing industry. Computers & Chemical Engineering , 28 , Article 5. 10.1016/j.compchemeng.2004.02.013.

Lim, AC and Zhou, YH and Washbrook, J and Titchener-Hooker, NJ and Farid, S (2004) A decisional-support tool to model the impact of regulatory compliance activities in the biomanufacturing industry. COMPUTERS & CHEMICAL ENGINEERING , 28 (5) 727 - 735. 10.1016/j.compchemeng.2004.02.013.

Lin, B and Dowling, M and Smith, M and Metcalf, N and Levy, MS and Farid, SS (2004) Technical and economical evaluation of tissue-engineered products for wound healing. In: (Proceedings) Smith and Nephew Student Day. : York.

Lye, GJ (2004) Automated microscale bioprocessing for the parallel evaluation of biocatalyst process options. In: (Proceedings) ProBio meeting on Micro and Nanoscale Technologies in Biocatalysis. : Swindon, UK.

Lye, GJ (2004) Membrane chromatography applications in plasmid DNA processing. In: (Proceedings) SCI Separation Science and Technology Group Meeting on Membrane Chromatography. : London.

Lye, GJ (2004) Microscale approaches to bioprocess design. In: (Proceedings) Parenteral Society meeting on Advances in Bioprocessing – Innovative Technologies, Manufacturing Issues. : Heathrow, London.

M

Mamma, D and Gerontas, S and Philippopoulos, CJ and Christakopoulos, P and Macris, BJ and Kekos, D (2004) Combined photo-assisted and biological treatment of industrial oily wastewater. J ENVIRON SCI HEAL A , 39 (3) 729 - 740. 10.1081/ESE-120027738.

Mason, C (2004) A bitter lesson, but tissue engineering learns to refocus on commercial realities. Clinica World Medical Device & Diagnostic News (1094) 14 - ?.

Mason, C and Markusen, JF and Town, MA and Dunnill, P and Wang, RK (2004) Doppler optical coherence tomography for measuring flow in engineered tissue. BIOSENSORS & BIOELECTRONICS , 20 (3) 414 - 423. 10.1016/j.bios.2004.03.035.

Mason, C and Markusen, JF and Town, MA and Dunnill, P and Wang, RK (2004) The potential of optical coherence tomography in the engineering of living tissue. PHYS MED BIOL , 49 (7) 1097 - 1115. 10.1088/0031-9155/49/7/002.

Mason, C. and Markusen, J.F. and Town, M.A. and Dunnill, P. and Wang, R.K. (2004) The potential of optical coherence tomography in the engineering of living tissue. Physics in Medicine and Biology , 49 (7) pp. 1097-1115. 10.1088/0031-9155/49/7/002.

Meacle, FJ and Lander, R and Shamlou, PA and Titchener-Hooker, NJ (2004) Impact of engineering flow conditions on plasmid DNA yield and purity in chemical cell lysis operations. BIOTECHNOL BIOENG , 87 (3) 293 - 302. 10.1002/bit.20114.

Micheletti, M and Baldi, S and Yeoh, SL and Ducci, A and Papadakis, G and Lee, KC and Yianneskis, M (2004) On spatial and temporal variations and estimates of energy dissipation in stirred reactors. Chemical Engineering Research and Design , 82 (A9) 1188 - 1198. 10.1205/cerd.82.9.1188.44172.

Micheletti, M and Yianneskis, M (2004) Study of fluid velocity characteristics in stirred solid-liquid suspensions with a refractive index matching technique. Proc. Instn. Mech Engrs. Part E: J. Process Mechanical Engineering , 218 191 - 204. 10.1243/0954408042466945.

Miller, OJ and Dalby, PA (2004) Exposing relationships using directed evolution. TRENDS BIOTECHNOL , 22 (5) 203 - 205. 10.1016/j.tibtech.2004.03.003.

Mukhopadhyay, T and Reddin, KM and Gorringe, A and Allison, N and Lye, GJ and Levy, MS (2004) The use of microwell technology and scale-down for rapid process development of a meningococcal vaccine based on outer membrane proteins from Neisseria Iactamica. In: (Proceedings) Biotechnology 2004, 12th International Biotechnology Symposium. : Santiago, Chile.

Mustafa, MA and Washbrook, J and Lim, AC and Zhou, Y and Titchener-Hooker, NJ and Morton, P and Berezenko, S and Farid, SS (2004) A software tool to assist business-process decision-making in the biopharmaceutical industry. Biotechnol Prog , 20 (4) 1096 - 1102. 10.1021/bp034377v.

Mustafa, MA and Washbrook, J and Lim, AC and Zhou, YH and Titchener-Hooker, NJ and Morton, P and Berezenko, S and Farid, SS (2004) A software tool to assist business-process decision-making in the biopharmaceutical industry. BIOTECHNOL PROGR , 20 (4) 1096 - 1102. 10.1021/bp034377v.

N

Neal, G and Francis, R and Shamlou, PA and Keshavarz-Moore, E (2004) Separation of immunoglobulin G precipitate from contaminating proteins using microfiltration. BIOTECHNOL APPL BIOC , 39 241 - 248.

O

O Kennedy, RD and Booth, A and Chan, G and Kong, S and Bracewell, DG and Willoughby, N and Relton, JM and Levy, SM (2004) Plasmid DNA for gene therapy and DNA vaccination : novel scale – down techniques for bioprocess operations. In: (Proceedings) Biotechnology 2004, 12th International Biotechnology Symposium. : Santiago, Chile.

P

Pate, ME and Turner, MK and Thornhill, NF and Titchener-Hooker, NJ (2004) Principal component analysis of nonlinear chromatography. BIOTECHNOL PROGR , 20 (1) 215 - 222. 10.1021/bp034133a.

Patel, R and Booth, AJ and Kuriyel, R and Hoare, M and Titchener-Hooker, NJ (2004) Engineering methods for the fast evaluation of tangential flow microfiltration operations within bioprocesses. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (pp. U123 - U123). AMER CHEMICAL SOC

Postlethwaite, J and Lamping, SR and Leach, GC and Hurwitz, MF and Lye, GJ (2004) Flux and transmission characteristics of a vibrating microfiltration system operated at high biomass loading. In: J MEMBRANE SCI. (pp. 89 - 101). ELSEVIER SCIENCE BV

Postlethwaite, J and Lamping, SR and Leach, GC and Titchener-Hooker, NJ (2004) Flux and transmission characteristics of a vibrating microfiltration system operated at high biomass loading. Journal of Membrane Science (228) 89 - 101.

R

Rajapakse, A and Titchener-Hooker, NJ and Farid, S (2004) Dynamic optimisation of the drug development pathway. In: Barbosa-Póvoa, A and Matos, H, (eds.) Computer-Aided Chemical Engineering. (pp. (on CD) - ?). Elsevier Science B.V.: Amsterdam.

Roberts, NJ and Seago, A and Carey, JS and Freer, R and Preston, C and Lye, GJ (2004) Lipase catalysed resolution of the Lotrafiban intermediate 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester in ionic liquids: comparison to the industrial t-butanol process. GREEN CHEM , 6 (9) 475 - 482. 10.1039/b405712k.

Rojanarata, T and Isarangkul, D and Wyakutta, S and Meevootisom, V and Woodley, JM (2004) Controlled release biocatalysis for the synthesis of D-phenylglycine. Biocatalysis and Biotransformations (22) 195 - 201.

S

Sayed, EK-M and E, HM (2004) Six monthly reports for LINK Biochemical Engineering (1990-1994).

Shitu, JO and Chartrain, M and Woodley, JM (2004) Flow Cytometric Analysis of Escherichia coli TOP10 pQR239 during a Baeyer-Villiger Monooxygenase Oxidation. In: (Proceedings) ESBES 5. : Stuttgart, Germany.

Shorrock, VJ and Chartrain, M and Woodley, JM (2004) An alternative bioreactor concept for application of an isolated oxidoreductase for asymmetric ketone reduction. Tetrahedron (60) 781 - 788.

Simaria, AS and Vilarinho, PM (2004) A genetic algorithm based approach to the mixed-model assembly line balancing problem of type II. COMPUT IND ENG , 47 (4) 391 - 407. 10.1016/j.cie.2004.09.001.

Siu, SC and Liau, J and Titchener-Hooker, NJ (2004) Quantifying the dispersive effects of fouling on a packed bed column using an extended reverse-flow technique. In: (Proceedings) European Symposium on Biochemical Engineering Science 5 (ESBES-5). : Stuttgart, Germany.

T

Tait, AS and Brown, CJ and Galbraith, DJ and Hines, MJ and Hoare, M and Birch, JR and James, DC (2004) Transient production of recombinant proteins by Chinese hamster ovary cells using polyethyleneimine/DNA complexes in combination with microtubule disrupting anti-mitotic agents. Biotechnology and Bioengineering (86) 296 - 297.

Tait, AS and Brown, CJ and Galbraith, DJ and Hines, MJ and Hoare, M and Birch, JR and James, DC (2004) Transient production of recombinant proteins by chinese hamster ovary cells using polyethyleneimine/DNA complexes in combination with microtubule disrupting anti-mitotic agents. In: BIOTECHNOL BIOENG. (pp. 707 - 721). JOHN WILEY & SONS INC

Titchener-Hooker, NJ and Ngiam, SH and King, JP and Zhou, Y (2004) Supporting the design and operation of chromatographic sequences through new graphical tools. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (pp. U211 - U211). AMER CHEMICAL SOC

Titchener-Hooker, NJ and Shamlou, PA and Lander, R and Meacle, FJ (2004) Impact of engineering flow conditions on plasmic DNA yeild and purity in chemical cell iysis operations. Biotechnology Progress , 20 (1) 215 - 222.

Titchener-Hooker, NJT and N F, T and M K, P and M, E (2004) Principal component analysis of nonlinear chromatography. Biotechnology Progress , 20 (1) 293 - 300.

U

Uzir, MH and Bishop, SR and Woodley, JM (2004) On the stability of a Biocatalytic process: A Case study on Enzyme-catalysed Baeyer-Villiger Reaction. In: (Proceedings) Biocat 2004: International Congress on Biocatalysis. : Hamburg, Germany.

Uzir, MH and Bishop, SR and Woodley, JM (2004) On the stability of a Biocatalytic process: A Case study on Enzyme-catalysed Baeyer-Villiger Reaction. In: (Proceedings) ESBES 5. : Stuttgart, Germany.

W

Williams-Dalson, W and Zhang, H and Lamping, S and Baganz, F and Hansen, K (2004) Use of a miniature bioreactor as a scale-up tool for mammalian cell culture. In: (Proceedings) Cell Culture Engineering IX. : Riviera Maya, QR, Mexico.

Willoughby, N and Martin, P and Titchener-Hooker, N (2004) Extreme scale-down of expanded bed adsorption: Purification of an antibody fragment directly from recombinant E. coli culture. BIOTECHNOLOGY AND BIOENGINEERING , 87 (5) 641 - 647. 10.1002/bit.20173.

Willoughby, NA and Bracewell, DG and Ngiam, SH and Baldascini, H and King, J and Titchener-Hooker, NJ (2004) Development of windows of operation for expanded bed adsorption. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (pp. U231 - U231). AMER CHEMICAL SOC

Woodley, JM and Lewis, D and Law, HEM (2004) UNSPECIFIED In: (Proceedings) Characterisation of a reaction to produce a biodegradable chelant by a carbon-nitrogen lyase.

Z

Zanzotto, A and Szita, N and Boccazzi, P and Lessard, P and Sinskey, AJ and Jensen, KF (2004) Membrane-aerated microbioreactor for high-throughput bioprocessing. BIOTECHNOL BIOENG , 87 (2) 243 - 254. 10.1002/bit.20140.

Zoro, BJH and Drake, RAL and Owen, SO and Hoare, M (2004) Automated bioprocessing of mammalian cells for regenerative medicine: cell loss in capillary flow. In: (Proceedings) Joint meeting of the Tissue Engineering Society International & European Tissue Engineering Society. : Lausanne, Switzerland.

This list was generated on Sat May 18 02:02:10 2013 BST.