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Number of items: 62.

A

ARRIS, CE; BLEASDALE, C; CALVERT, AH; CURTIN, NJ; DALBY, C; GOLDING, BT; ... NEWELL, DR; + view all (1994) PROBING THE ACTIVE-SITE AND MECHANISM OF ACTION OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE WITH SUBSTRATE-ANALOGS TO (O-6-SUBSTITUTED GUANINES). ANTI-CANCER DRUG DES , 9 (5) 401 - 408.

B

BEVERLEY, PCL; SADOVNIKOVA, E; ZHU, X; HICKLING, J; GAO, L; CHAIN, B; ... STAUSS, HJ; + view all (1994) STRATEGIES FOR STUDYING MOUSE AND HUMAN IMMUNE-RESPONSES TO HUMAN PAPILLOMAVIRUS TYPE-16. In: Chadwick, DJ and Marsh, J, (eds.) VACCINES AGAINST VIRALLY INDUCED CANCERS. (pp. 78 - 96). JOHN WILEY & SONS LTD

BISSET, GMF; BAVETSIAS, V; THORNTON, TJ; PAWELCZAK, K; CALVERT, AH; HUGHES, LR; JACKMAN, AL; (1994) THE SYNTHESIS AND THYMIDYLATE SYNTHASE INHIBITORY ACTIVITY OF L-GAMMA-L-LINKED DIPEPTIDE AND L-GAMMA-AMIDE ANALOGS OF 2-DESAMINO-2-METHYL-N(10)-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583). J MED CHEM , 37 (20) 3294 - 3302.

BLEEHEN, NM; CALVERT, AH; LEE, SM; HARPER, P; KAYE, SB; JUDSON, I; BRAMPTON, M; (1994) A CANCER-RESEARCH CAMPAIGN (CRC) PHASE-II TRIAL OF CB10-277 GIVEN BY 24-HOUR INFUSION FOR MALIGNANT-MELANOMA. BRIT J CANCER , 70 (4) 775 - 777.

Bleehen, NM; Calvert, AH; Lee, SM; Harper, P; Kaye, SB; Judson, I; Brampton, M; (1994) Cancer Research Campaign (CRC) phase II trial of CB 10-277 given by 24 hour infusion for malignant melanoma. British Journal of Cancer , 70 (4) 775 - 777.

BOXER, GM; ABASSI, AM; PEDLEY, RB; BEGENT, RHJ; (1994) LOCALIZATION OF MONOCLONAL-ANTIBODIES REACTING WITH DIFFERENT EPITOPES ON CARCINOEMBRYONIC ANTIGEN (CEA) - IMPLICATIONS FOR TARGETED THERAPY. BRIT J CANCER , 69 (2) 307 - 314.

Boxer, GMP; R, B; (1994) Antibody cocktails show enhanced potential for targeted therapy. In: (Proceedings) Proceedings BACR, Br J Cancer. (pp. 15 - ?).

BRIDGEWATER, JA; SOUHAMI, RL; ALLGROVE, J; KENDALL, B; PRITCHARD, J; (1994) INTRACRANIAL GERM-CELL TUMORS PRESENTING WITH HYPOPITUITARISM - SUCCESSFUL TREATMENT WITH CHEMOTHERAPY ALONE. EUR J CANCER , 30A (9) 1401 - 1403.

C

CALVERT, AH; (1994) DOSE OPTIMIZATION OF CARBOPLATIN IN ADULTS. ANTICANCER RESEARCH , 14 (6A) 2273 - 2277.

CALVERT, AH; LIND, MJ; GHAZALASWAD, S; GUMBRELL, L; MILLWARD, MJ; BAILEY, NP; ... MIDDLETON, I; + view all (1994) CARBOPLATIN AND GRANULOCYTE-COLONY-STIMULATING FACTOR AS FIRST-LINE TREATMENT FOR EPITHELIAL OVARIAN-CANCER - A PHASE-I DOSE-INTENSITY ESCALATION STUDY. SEMIN ONCOL , 21 (5) 1 - 6.

Casey, JL; Keep, PA; Chester, KA; Robson, L; Hawkins, R; Pedley, RBB; R, HJ; (1994) A comparitive tumour targeting study of a crosslinked hF(ab')2 fragment and a chemically crosslinked hF(ab')2 version of a CEA antibody. In: (Proceedings) Proceedings BACR, Br J Cancer. (pp. 34 - ?).

CHESTER, KA; BEGENT, RHJ; ROBSON, L; KEEP, P; PEDLEY, RB; BODEN, JA; ... HAWKINS, RE; + view all (1994) PHAGE LIBRARIES FOR GENERATION OF CLINICALLY USEFUL ANTIBODIES. LANCET , 343 (8895) 455 - 456.

Chester, KA; Begent, RHJ; Robson, L; Keep, PA; Pedley, RB; Boden, J; ... and Hawkins, RE; + view all (1994) Filamentous phage antibodies: the power of selection for clinical use. In: New Antibody technology and the Emergence of Useful Cancer Therapy.

CHESTER, KA; BEGENT, RHJ; ROBSON, L; KEEP, PA; PEDLEY, RB; BODEN, J; ... HAWKINS, RE; + view all (1994) PRODUCTION OF A HIGH-AFFINITY ANTI-CEA SCFV FOR COLORECTAL TUMOR TARGETING. In: J CELL BIOCHEM. (pp. 198 - 198). WILEY-LISS

Chester, KA; Begent, RHJ; Robson, L; Keep, PA; Pedley, RB; Boden, J; ... Hawkins, REF; + view all (1994) Production of a high-affinity anti-CEA SCFV for colorectal tumour targeting. In: Journal of Cellular Biochemistry. (pp. 198 - 198).

Chester, KA; Begent, RHJ; Robson, L; Keep, PA; Pedley, RB; Boden, J; ... R, E; + view all (1994) A high affinity anti-CEA scFv for tumour targeting produced in filamentous phage. In: (Proceedings) Proceedings BACR, Br J Cancer. (pp. 15 - ?).

CHESTER, KA; ROBSON, L; KEEP, PA; PEDLEY, RB; BODEN, JA; BOXER, GM; ... BEGENT, RHJ; + view all (1994) PRODUCTION AND TUMOR-BINDING CHARACTERIZATION OF A CHIMERIC ANTI-CEA FAB EXPRESSED IN ESCHERICHIA-COLI. INT J CANCER , 57 (1) 67 - 72.

Cochet, O; Prospero, T; Chester, K; Teillaud, JL; Winter, G; Hawknis, RE; (1994) Bivalent and bispecific diabodies for colorectal tumour targeting. In: Journal of Cellular Biochemistry. (pp. 211 - 211).

F

Fentiman, IS; Howell, A; Hamed, H; Lee, SM; Ranson, M; Walls, J; ... Rubens, RD; + view all (1994) A controlled trial of adjuvant tamoxifen, with or without prednisolone, in postmenopausal women with operable breast cancer. British Journal of Cancer , 70 (4) 729 - 731.

FORROW, S; LEE, M; SOUHAMI, RL; HARTLEY, JA; (1994) THE EFFECT OF AT AND GC SEQUENCE-SPECIFIC MINOR-GROOVE BINDING-AGENTS ON RESTRICTION-ENDONUCLEASE ACTIVITY. ABSTR PAP AM CHEM S , 208 97 - MEDI.

G

GOEDHALS, L; JORDAAN, JP; KAYE, SB; ARMAND, JP; VEENHOF, CHN; FALKSON, G; ... BROHEE, D; + view all (1994) A DOSE-FINDING STUDY OF GRANISETRON, A NOVEL ANTIEMETIC, IN PATIENTS RECEIVING HIGH-DOSE CISPLATIN. SUPPORT CARE CANCER , 2 (3) 177 - 183.

GRIMALDI, KA; BINGHAM, JP; SOUHAMI, RL; HARTLEY, JA; (1994) DNA-DAMAGE BY ANTICANCER AGENTS AND ITS REPAIR - MAPPING IN CELLS AT THE SUBGENE LEVEL WITH QUANTITATIVE POLYMERASE CHAIN-REACTION. ANAL BIOCHEM , 222 (1) 236 - 242.

GRIMALDI, KA; MCADAM, SR; SOUHAMI, RL; HARTLEY, JA; (1994) DNA-DAMAGE BY ANTICANCER AGENTS RESOLVED AT THE NUCLEOTIDE LEVEL OF A SINGLE-COPY GENE - EVIDENCE FOR A NOVEL BINDING-SITE FOR CISPLATIN IN CELLS. NUCLEIC ACIDS RES , 22 (12) 2311 - 2317. Gold open access

H

HARTLEY, JA; MCADAM, SR; DAS, S; ROLDAN, MC; HASKELL, MK; LEE, M; (1994) MOLECULAR AND CELLULAR PHARMACOLOGY OF NOVEL PHOTOACTIVE PSORALEN AND COUMARIN CONJUGATES OF PYRROLE-CONTAINING AND IMIDAZOLE-CONTAINING ANALOGS OF NETROPSIN. ANTI-CANCER DRUG DES , 9 (3) 181 - 197.

HARTLEY, JA; WYATT, MD; GARBIRAS, BJ; RICHTER, C; LEE, M; (1994) PROBING THE IMPORTANCE OF THE 2ND CHLOROETHYL ARM OF A BENZOIC-ACID MUSTARD DERIVATIVE OF AN IMIDAZOLE-CONTAINING ANALOG OF DISTAMYCIN. BIOORG MED CHEM LETT , 4 (20) 2421 - 2424.

HARTLEY, JM; HANSEN, L; HARLAND, SJ; NICHOLSON, PW; PASINI, F; SOUHAMI, RL; (1994) METABOLISM OF IFOSFAMIDE DURING A 3 DAY INFUSION. BRIT J CANCER , 69 (5) 931 - 936.

K

KELLY, KM; BEVERLEY, PCL; CHU, AC; DAVENPORT, V; GORDON, I; SMITH, M; PRITCHARD, J; (1994) SUCCESSFUL IN-VIVO IMMUNOLOCALIZATION OF LANGERHANS CELL HISTIOCYTOSIS WITH USE OF A MONOCLONAL-ANTIBODY, NA1/34. J PEDIATR , 125 (5) 717 - 722.

KING, DJ; TURNER, A; FARNSWORTH, APH; ADAIR, JR; OWENS, RJ; PEDLEY, RB; ... YARRANTON, GT; + view all (1994) IMPROVED TUMOR TARGETING WITH CHEMICALLY CROSS-LINKED RECOMBINANT ANTIBODY FRAGMENTS. CANCER RES , 54 (23) 6176 - 6185.

L

LANE, DM; EAGLE, KF; BEGENT, RHJ; HOPESTONE, LD; GREEN, AJ; CASEY, JL; ... HILSON, AJW; + view all (1994) RADIOIMMUNOTHERAPY OF METASTATIC COLORECTAL TUMORS WITH IODINE-131-LABELED ANTIBODY TO CARCINOEMBRYONIC ANTIGEN - PHASE I/II STUDY WITH COMPARATIVE BIODISTRIBUTION OF INTACT AND F(AB')(2) ANTIBODIES. BRIT J CANCER , 70 (3) 521 - 525.

LEE, M; ROLDAN, MC; HASKELL, MK; MCADAM, SR; HARTLEY, JA; (1994) IN-VITRO PHOTOINDUCED CYTOTOXICITY AND DNA-BINDING PROPERTIES OF PSORALEN AND COUMARIN CONJUGATES OF NETROPSIN ANALOGS - DNA SEQUENCE-DIRECTED ALKYLATION AND CROSS-LINK FORMATION. J MED CHEM , 37 (8) 1208 - 1213.

LEE, M; WALKER, C; COOPER, M; FORROW, SM; HARTLEY, JA; (1994) SEQUENCE SELECTIVE MOLECULAR RECOGNITION OF LONG DNA-SEQUENCES BY OLIGOMETHYLENE-LINKED OLIGOIMIDAZOLE ANALOGS OF DISTAMYCIN. J BIOACT COMPAT POL , 9 (1) 3 - 28.

Lee, SM; Margison, GP; Thatcher, N; O'Connor, PJ; Cooper, DP; (1994) Formation and loss of 06-methyldeoxyguanosine in human leukocyte DNA following sequential DTIC and fotemustine chemotherapy. British Journal of Cancer , 69 (5) 853 - 857.

Lee, SM; O'Connor, PJ; Thatcher, N; Crowther, D; Margison, G; Cooper, DP; (1994) Relationship between 06-alkylguanine-DNA alkyltransferase levels and 06-methyldeoxyguanosine formation in peripheral blood cells of patients receiving CBI0-277. In: (Proceedings) 1994 AACR Annual meeting/85th Annual Meeting, San Francisco, CA.. (pp. 468 - ?). Proc Am Assoc Cancer Res

Lee, SM; O'Connor, PJ; Thatcher, N; Crowther, D; Margison, GP; Cooper, DP; (1994) Relationships between the formation of 06-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and 06-alkylguanine-DNA-alkyltransferase in human peripheral leukocytes. Cancer Research , 54 (15) 4072 - 4076.

Lee, SM; Thatcher, N; Crowther, D; Margison, GP; (1994) In vivo depletion of human 06-alkylguanine-DNA alkyltransferase by temozolomide. In: (Proceedings) 8th NCI-EORTC Symposium on New Drugs in Cancer Therapy, Amsterdam.. (pp. 79 - ?). Clinical Cancer Research

Lee, SM; Thatcher, N; Crowther, D; Margison, GP; (1994) Inactivation of human O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide. British Journal of Cancer , 69 (3) 452 - 456.

Lee, SM; Wong, NW; (1994) Survival in hepatitis-B cirrhosis compared to alcoholic cirrhosis in patients with Child's C liver disease: a prospective study of endoscopic sclerotherapy for bleeding oesophageal varices. Singapore Medical Journal , 35 (1) 53 - 56.

LIEW, FY; FRAZER, I; MOSS, DJ; DOHERTY, PC; WETTSTEIN, FO; BEVERLEY, PCL; ... ARRAND, JR; + view all (1994) STERILE IMMUNITY - GENERAL DISCUSSION-I. In: Chadwick, DJ and Marsh, J, (eds.) VACCINES AGAINST VIRALLY INDUCED CANCERS. (pp. 45 - 46). JOHN WILEY & SONS LTD

LOFLIN, PT; HOCHHAUSER, D; HICKSON, ID; MORALES, F; ZWELLING, LA; (1994) MOLECULAR ANALYSIS OF A POTENTIALLY PHORBOL-REGULATABLE REGION OF THE HUMAN TOPOISOMERASE II-ALPHA GENE PROMOTER. BIOCHEM BIOPH RES CO , 200 (1) 489 - 496.

M

MARSHALL, D; PEDLEY, RB; BODEN, JA; BODEN, R; BEGENT, RHJ; (1994) CLEARANCE OF CIRCULATING RADIO-ANTIBODIES USING STREPTAVIDIN OR 2ND ANTIBODIES IN A XENOGRAFT MODEL. BRIT J CANCER , 69 (3) 502 - 507.

Marshall, D; Pedley, RB; Melton, RG; Boden, JA; Boden, RB; R, HJ; (1994) Galactosylated streptavidin as a clearing agent for biotinylated anti-tumour antibodies in radioimmunotargeting. In: (Proceedings) Proceedings BACR, Br J Cancer. (pp. 34 - ?).

N

NICULESCUDUVAZ, I; PEDLEY, RB; SPRINGER, CJ; (1994) NEW PRODRUGS FOR ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT). PROCEEDINGS OF THE XVI INTERNATIONAL CANCER CONGRESS - FREE PAPERS AND POSTERS, TOMES 1-4 2779 - 2782.

O

OLABIRAN, Y; LEDERMANN, JA; MARSTON, NJ; BOXER, GM; HICKS, R; SOUHAMI, RL; ... STAHEL, RA; + view all (1994) THE SELECTION OF ANTIBODIES FOR TARGETED THERAPY OF SMALL-CELL LUNG-CANCER (SCLC) USING A HUMAN TUMOR SPHEROID MODEL TO COMPARE THE UPTAKE OF CLUSTER-1 AND CLUSTER-W4 ANTIBODIES. BRIT J CANCER , 69 (2) 247 - 252.

Ornadel, D; Souhami, RL; Whelan, J; Nooy, M; Ruiz de Elvira, C; Pringle, J; ... Bridgewater, J; + view all (1994) Doxorubicin and cisplatin with granulocyte colony-stimulating factor as adjuvant chemotherapy for osteosarcoma: phase II trial of the European Osteosarcoma Intergroup. J Clin Oncol , 12 (9) 1842 - 1848.

P

PEDLEY, RB; BEGENT, RHJ; BODEN, JA; BOXER, GM; BODEN, R; KEEP, PA; (1994) ENHANCEMENT OF RADIOIMMUNOTHERAPY BY DRUGS MODIFYING TUMOR BLOOD-FLOW IN A COLONIC XENOGRAFT MODEL. INT J CANCER , 57 (6) 830 - 835.

PEDLEY, RB; BODEN, JA; BODEN, R; BEGENT, RHJ; TURNER, A; HAINES, AMR; KING, DJ; (1994) THE POTENTIAL FOR ENHANCED TUMOR-LOCALIZATION BY POLY(ETHYLENE GLYCOL) MODIFICATION OF ANTI-CEA ANTIBODY. BRIT J CANCER , 70 (6) 1126 - 1130.

R

Radford, JA; Whelan, JS; Harris, M; Stansfeld, AG; Deakin, D; Swindell, R; ... Crowther, D; + view all (1994) Weekly VAPEC-B chemotherapy for high grade non-Hodgkin's lymphoma: results of treatment in 184 patients. Annals of Oncology , 5 (2) 147 - 151.

Rodriguez-Viciana, P; Warne, PH; Dhand, R; Vanhaesebroeck, B; Gout, I; Fry, MJ; ... Downward, J; + view all (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature , 370 (6490) 527 - 532. 10.1038/370527a0.

Rohatiner, AZS; Johnson, PWM; Price, CGA; Arnott, SJ; Amess, JAL; Norton, AJ; ... Lister, TA; + view all (1994) Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for recurrent low grade B cell lymphoma. Journal of Clinical Oncology , 12 1177 - 1184.

Rohatiner, AZS; Whelan, JS; Ganjoo, RK; Norton, AJ; Wilson, A; Lister, TA; (1994) Mediastinal large cell lymphoma with sclerosis. British Journal of Cancer , 69 601 - 604.

S

SANGHANI, PC; JACKMAN, A; EVANS, VR; THORNTON, T; HUGHES, L; CALVERT, AH; MORAN, RG; (1994) A STRATEGY FOR THE DESIGN OF MEMBRANE-PERMEABLE FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE INHIBITORS - BAY-REGION-SUBSTITUTED 2-DESAMINO-2-METHYL-5,8-DIDEAZAFOLATE ANALOGS. MOL PHARMACOL , 45 (2) 341 - 351.

Short, S; (1994) UNSPECIFIED In: (Proceedings) Annual Scientific Meeting of The Royal College of Radiologists.

SIMPSON, JE; LEE, M; MCADAMS, S; HARTLEY, JA; (1994) CELLULAR AND MOLECULAR PHARMACOLOGY OF A SERIES OF DNA MINOR-GROOVE AND SEQUENCE DIRECTED PHOTOINDUCED CROSS-LINKING AGENTS. ABSTR PAP AM CHEM S , 208 96 - MEDI.

SMELLIE, M; KELLAND, LR; THURSTON, DE; SOUHAMI, RL; HARTLEY, JA; (1994) CELLULAR PHARMACOLOGY OF NOVEL C8-LINKED ANTHRAMYCIN-BASED SEQUENCE-SELECTIVE DNA MINOR-GROOVE CROSS-LINKING AGENTS. BRIT J CANCER , 70 (1) 48 - 53.

SOO, KS; STRAUSS, HJ; BEVERLEY, PCL; WYLLIE, JH; (1994) INDUCTION OF T-CELL-MEDIATED TUMOR REJECTION BY B7 GENE-THERAPY. BRIT J SURG , 81 (12) 1801 - 1801.

SPRINGER, CJ; NICULESCUDUVAZ, I; PEDLEY, RB; (1994) NOVEL PRODRUGS OF ALKYLATING-AGENTS DERIVED FROM 2-FLUOROBENZOIC AND 3-FLUOROBENZOIC ACIDS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY. J MED CHEM , 37 (15) 2361 - 2370.

T

TCHILIAN, EZ; BEVERLEY, PCL; YOUNG, BD; WATT, SM; (1994) MOLECULAR-CLONING OF 2 ISOFORMS OF THE MURINE HOMOLOG OF THE MYELOID CD33 ANTIGEN. BLOOD , 83 (11) 3188 - 3198.

TURNER, A; KING, DJ; FARNSWORTH, APH; RHIND, SK; PEDLEY, RB; BODEN, J; ... PARKER, D; + view all (1994) COMPARATIVE BIODISTRIBUTIONS OF INDIUM-111-LABELED MACROCYCLE CHIMERIC B72.3 ANTIBODY CONJUGATES IN TUMOR-BEARING MICE. BRIT J CANCER , 70 (1) 35 - 41.

V

Vandenabeele, P; Goossens, V; Beyaert, R; Declercq, W; Grooten, J; Vanhaesebroeck, B; ... Denecker, G; + view all (1994) Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. Circ Shock , 44 (4) 196 - 200.

W

Whelan, JS; Smith, TA; Phear, GA; Rohatiner, AZS; Lister, TA; Meuth, M; (1994) Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase. Leukemia , 8 264 - 265.

WYATT, MD; GARBIRAS, BJ; HASKELL, MK; LEE, M; SOUHAMI, RL; HARTLEY, JA; (1994) STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF NITROGEN MUSTARD-CONTAINING AND PYRROLE-CONTAINING MINOR GROOVE-BINDING AGENTS RELATED TO DISTAMYCIN. ANTI-CANCER DRUG DES , 9 (6) 511 - 525.

WYATT, MD; GARBIRAS, BJ; LEE, M; FORROW, SM; HARTLEY, JA; (1994) SYNTHESIS AND DNA-BINDING PROPERTIES OF A SERIES OF N TO C LINKED AND IMIDAZOLE-CONTAINING ANALOGS OF DISTAMYCIN. BIOORG MED CHEM LETT , 4 (6) 801 - 806.

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