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Number of items: 132.

A

Ah-See, MW and Makris, A and Taylor, NJ and Harrison, M and Ostler, PJ and Richman, PI and Stirling, JJ and Burcombe, RJ and Leach, MO and Pittam, MR and Ravichandran, D and D'Arcy, JA and Padhani, A (2004) Changes in dynamic contrast-enhanced MRI as an early predictor of response to neoadjuvant chemotherapy in primary breast cancer. British Journal of Cancer , 91 S22 - S22.

Ah-See, MW and Padhani, AR and Taylor, NJ and Daley, FM and Bentzen, SM and Burcombe, RJ and Harrison, M and Stirling, JJ and Leach, MO and Makris, A (2004) Tumour microvasculature, assessment by dynamic contrast- enhanced MRI fails to correlate with VEGF expression in breast cancer biopsies. British Journal of Cancer , 91 S16 - S16.

Akbar, AN and Beverley, PCL and Salmon, M (2004) Opinion - Will telomere erosion lead to a loss of T-cell memory? NAT REV IMMUNOL , 4 (9) 737 - 743. 10.1038/nri1440.

Alley, MC and Hollingshead, MG and Pacula-Cox, CM and Wand, WR and Hartley, JA and Howard, PW and Gregson, SJ and Thurston, DE and Sausville, EA (2004) SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 2: Efficacy evaluations. CANCER RES , 64 (18) 6700 - 6706.

André, T and Boni, C and Mounedji-Boudiaf, L and Navarro, M and Tabernero, J and Hickish, T and Topham, C and Zaninelli, M and Clingan, P and Bridgewater, J and Tabah-Fisch, I and de Gramont, A and Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators, (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med , 350 (23) 2343 - 2351. 10.1056/NEJMoa032709.
An open access version is available from UCL Discovery

Ansari, J and Nagabhushan, N and Bomanji, J and Bacon, C and Lee, SM (2004) Small cell lung cancer associated with anti-Hu paraneoplastic sensory neuropathy and peripheral nerve microvasculitis: Case report and literature review. Clinical Oncology , 16 (1) 71 - 76.

Arkenau, HT and Porschen, R (2004) Adjuvant chemotherapy in curative resected colon carcinoma | Adjuvante chemotherapie des kurativ resezierten kolonkarzinoms. Verdauungskrankheiten , 22 (4) 208 - 215.

Arkenau, HT and Porschen, R (2004) Adjuvante Therapie des kolorektalen Karzinoms. Verdauungskrankheiten 208 - 215.

B

Bagshawe, KD and Sharma, SK and Begent, RHJ (2004) Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. EXPERT OPIN BIOL TH , 4 (11) 1777 - 1789. 10.1517/14712598.4.11.1777.

Baraldi, PG and Beria, I and Cozzi, P and Geroni, C and Espinosa, A and Gallo, MA and Entrena, A and Bingham, JP and Hartley, JA and Romagnoli, R (2004) Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies. BIOORGAN MED CHEM , 12 (14) 3911 - 3921. 10.1016/j.bmc.2004.04.045.

BBC, NO (2004) Drug boosts lung cancer survival. UNSPECIFIED

BBC, NORCR (2004) 'They just didn't know what it would do'. UNSPECIFIED

BBC News at Ten BBC news correspondent, AM (2004) Passive smoking is a public health hazard. UNSPECIFIED

BBC News at Ten BBC news correspondent, AM (2004) Smart drug for lung cancer tested. UNSPECIFIED

Bentzen, SM and Bernier, J and Khalil, AA and Saunders, MI and Horiot, JC and Van den Bogaert, W and Cummings, BJ and Dische, S (2004) Estimatet effect of patient non-compliance to dose-time constraints in five randomized clinical trials of altered fractionation in radiotherapy for head-and-neck carcinomas. Strahlentherapie und Onkologie , 180 98 - 98.

Birtle, AJ and Newby, JC and Harland, SJ (2004) Epirubicin carboplatin and 5-fluorouracil (ECarboF) chemotherapy in metastatic hormone refractory prostate cancer. British Journal of Cancer , 91 (8) 1472 - 1476.

Bownes, P and Hoskin, PJ and Ostler, PJ and Lowe, GJ and Bryant, L (2004) Quality assurance for fractionated high dose rate afterloading brachytherapy as monotherapy for prostate cancer. Radiotherapy and Oncology , 71 241 - ?.

Burroughs, A and Hochhauser, D and Meyer, T (2004) Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. LANCET ONCOL , 5 (7) 409 - 418.

Burroughs, A and Hochhauser, D and Meyer, T (2004) Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol , 5 (7) 409 - 418. 10.1016/S1470-2045(04)01508-6.

C

Calabrese, CR and Almassy, R and Barton, S and Batey, MA and Calvert, AH and Canan-Koch, S and Durkacz, BW and Hostomsky, Z and Kumpf, RA and Kyle, S and Li, J and Maegley, K and Newell, DR and Notarianni, E and Stratford, IJ and Skalitzky, D and Thomas, HD and Wang, LZ and Webber, SE and Williams, KJ and Curtin, NJ (2004) Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J NATL CANCER I , 96 (1) 56 - 67. 10.1093/jnci/djh005.

Calvert, AH (2004) Biochemical pharmacology of pemetrexed. Oncology (Williston Park) , 18 (13 Suppl 8) 13 - 17.

Cansick, JC and Lennon, R and Cummins, CL and Howie, AJ and McGraw, ME and Saleem, MA and Tizard, EJ and Hulton, SA and Milford, DV and Taylor, CM (2004) Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative)glomerulonephritis. Nephrology Dialysis Transplantation , 19 2769 - 2777.

Carnell, DM and Smith, RE and Daley, FM and Barber, PR and Hoskin, PJ and Wilson, GD and Murray, GI and Everett, SA (2004) Target validation of cytochrome P450CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. International Journal of Radiation Oncology Biology Physics , 58 (2) 500 - 509.

Channel, 4IMF (2004) Happy Birthday Thalidomide. UNSPECIFIED

Chester, JD and Hall, GD and Forster, MD and Protheroe, AS (2004) Systemic Chemotherapy for Patients with Bladder Cancer- Current Controversies and Future Directions. Cancer Treat Rev. , 30 (4) 343 - 358.

Chester, K and Pedley, B and Tolner, B and Violet, J and Mayer, A and Sharma, S and Boxer, G and Green, A and Nagl, S and Begent, R (2004) Engineering antibodies for clinical applications in cancer. Tumor Biology , 25 (1-2) 91 - 98.

Chew, SK and Akdemir, F and Chen, P and Lu, WJ and Mills, K and Daish, T and Kumar, S and Rodriguez, A and Abrams, JM (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell , 7 (6) 897 - 907. 10.1016/j.devcel.2004.09.016.

Chowdhury, S and Chester, KA and Bridgewater, J and Collins, MK and Martin, F (2004) Efficient retroviral vector targeting of carcinoembryonic antigen-positive tumors. MOL THER , 9 (1) 85 - 92. 10.1016/j.ymthe.2003.10.004.

Clamp, A and Adams, M and Atkinson, R and Boven, E and Calvert, AH and Cervantes, A and Ganesan, T and Lotz, J and Vasey, P and Cheverton, P and Jayson, GC (2004) A phase IIA study of the topoisomerase I inhibitor, exatecan mesylate (DX-895 1f), administered at two different dose schedules in patients with platinum- and taxane-resistant/refractory ovarian cancer. GYNECOL ONCOL , 95 (1) 114 - 119. 10.1016/j.ygyno.2004.06.047.

Clingen, PH and Wu, J and Prise, KM and Hartley, JA (2004) H2AX nuclear foci are induced in human cells after treatment with DNA interstrand crosslinking chemotherapeutics. BRITISH JOURNAL OF CANCER , 91 S48 - S48.

Curtin, NJ and Barlow, HC and Bowman, KJ and Calvert, AH and Davison, R and Golding, BT and Huang, B and Loughlin, PJ and Newell, DR and Smith, PG and Griffin, RJ (2004) Resistance-modifying agents. 11. Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha(1)-acid glycoprotein. J MED CHEM , 47 (20) 4905 - 4922. 10.1021/jm040772w.

D

Dearling, JLJ and Flynn, AA and Sutcliffe-Goulden, J and Petrie, IA and Boden, R and Green, AJ and Boxer, GM and Begent, RHJ and Pedley, RB (2004) Analysis of the regional uptake of radiolabeled deoxyglucose analogs in human tumor xenografts. J NUCL MED , 45 (1) 101 - 107.

Dumez, H and Van Oosterom, AT and Rothermel, JD and Mull, R and Calvert, AH (2004) Phase Ib/Il dose-escalation trial evaluating the safety and tolerability of EP0906 plus capecitabine in patients with advanced cancer. Journal of Clinical Oncology , 22 (14) 2093 - ?.

E

Eardley, KS and Ferreriera, MAS and Howie, AJ and Gosling, P and Lipkin, GW (2004) Urinary albumin excretion: a predictor of glomerular findings in microscopic haematuria. QJM , 97 297 - 301.

F

Ffolkes, LV and Freeman, A and Harland, SJ and Parkinson, MC (2004) Are there diagnostic problems with testis tumours? JOURNAL OF PATHOLOGY , 204 35A - 35A.

Flores, L and Henry, J and Bailey, S and Tahberhai, Z and Harris, D and Buchmueller, K and Nguyen, B and Wilson, D and Kotecha, M and Hochhauser, D and Hartley, J and Lee, M (2004) JH-37, a hairpin polyamide, inhibits the binding of nuclear factor-Y to inverted CCAAT boxes in the human topoisomerase II alpha promoter. A biochemical and biophysical study. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (pp. U26 - U27). AMER CHEMICAL SOC

Forster, MD and Madhusudan, S and Muthuramalingam, SR and Braybrooke, JP and Wilner, S and Kaur, K and Han, C and Hoare, S and Balkwill, F and Talbot, DC and Ganesan, TS and Harris, AL (2004) A phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor alpha Inhibitor in Patients with Metastatic Breast Cancer. Clin Cancer Res. , 10 (19) 6528 - 6534.

Francis, RJ and Mather, SJ and Chester, K and Sharma, SK and Bhatia, J and Pedley, RB and Waibel, R and Green, AJ and Begent, RHJ (2004) Radiolabelling of glycosylated MFE-23 :: CPG2 fusion protein (MFECP1) with Tc-99m for quantitation of tumour antibody-enzyme localisation in antibody-directed enzyme pro-drug therapy (ADEPT). EUR J NUCL MED MOL I , 31 (8) 1090 - 1096. 10.1007/s00259-004-1474-4.

Friedmann, B and Caplin, M and Hartley, JA and Hochhauser, D (2004) Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839). CLIN CANCER RES , 10 (19) 6476 - 6486.

G

Giampieri, S and Garcia-Escudero, R and Green, J and Storey, A (2004) Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation. ONCOGENE , 23 (34) 5864 - 5870. 10.1038/sj.onc.1207711.

Giampieri, S and Storey, A (2004) Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from humanpapillomaviruses types 5 and 18. BRIT J CANCER , 90 (11) 2203 - 2209. 10.1038/sj.bjc.6601829.

Graff, CP and Chester, K and Begent, R and Wittrup, KD (2004) Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C. PROTEIN ENG DES SEL , 17 (4) 293 - 304. 10.1093/protein/gzh038.

Green, A and Flynn, A and Pedley, RB and Dearling, J and Begent, R (2004) Nonuniform absorbed dose distribution in the kidney: The influence of organ architecture. Cancer Biotherapy and Radiopharmaceuticals , 19 (3) 371 - 377.

Green, A and Flynn, A and Pedley, RB and Dearling, J and Begent, R (2004) Nonuniform absorbed dose distribution in the kidney: The influence of organ architecture. CANCER BIOTHER RADIO , 19 (3) 371 - 377.

Gregson, SJ and Howard, PW and Gullick, DR and Hamaguchi, A and Corcoran, KE and Brooks, NA and Hartley, JA and Jenkins, TC and Patel, S and Guille, MJ and Thurston, DE (2004) Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8 ' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers. J MED CHEM , 47 (5) 1161 - 1174. 10.1021/jm0308971.

H

Harney, J and Shah, N and Short, S and Daley, F and Groom, N and Wilson, GD and Joiner, MC and Saunders, MI (2004) The evaluation of low dose hyper-radiosensitivity in normal human skin. Radiotherapy and Oncology , 70 (3) 319 - 329. 10.1016/j.radonc.2004.01.015.

Harney, J and Short, S and Shah, N and Joiner, M and Saunders, MI (2004) Low dose hyper-radiosensitivity in metastatic tumors. International Journal of Radiation Oncology Biology Physics , 59 (4) 1190 - 1195. 10.1016/j.ijrobp.2003.12.029.

Hartley, JA (2004) Assessing individual responses to anti-cancer therapy using the comet assay. Mutagenesis , 19 (6) 15 - ?.

Hartley, JA (2004) Assessing individual responses to anti-cancer therapy using the comet assay. MUTAGENESIS , 19 (6) 504 - 504.

Hartley, JA and Spanswick, VJ and Brooks, N and Clingen, PH and McHugh, PJ and Hochhauser, D and Pedley, RB and Kelland, LR and Alley, MC and Schultz, R and Hollingshead, MG and Schweikart, KM and Tomaszewski, JE and Sausville, EA and Gregson, SJ and Howard, PW and Thurston, DE (2004) SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 1: Cellular pharmacology, in vitro and initial in vivo antitumor activity. CANCER RES , 64 (18) 6693 - 6699.

Hartley, JA and Spanswick, VJ and Brooks, N and Clingen, PH and McHugh, PJ and Hochhauser, D and Pedley, RB and Kelland, LR and Alley, MC and Schultz, R and Hollingshead, MG and Schweikart, KM and Tomaszewski, JE and Sausville, EA and Gregson, SJ and Howard, PW and Thurston, DE (2004) SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity. Cancer Res , 64 (18) 6693 - 6699. 10.1158/0008-5472.CAN-03-2941.

Helena Selby, BBCWSABBCR4 (2004) BBC World Service Health Matters Programme on Lung Cancer. UNSPECIFIED

Henry, JA and Le, NM and Nguyen, B and Howard, CM and Bailey, SL and Horick, SM and Buchmueller, KL and Kotecha, M and Hochhauser, D and Hartley, JA and Wilson, WD and Lee, M (2004) Targeting the inverted CCAAT box 2 in the topoisomerase II alpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: Design, synthesis, molecular biology, and biophysical studies. BIOCHEMISTRY-US , 43 (38) 12249 - 12257. 10.1021/bi048785z.

Hoskin, PJ (2004) Should all breast cancer patients with symptomatic bone metastasis be treated with bisphosphonates? The case against. Clinical Oncology , 16 (2) 112 - 114.

Hoskin, PJ (2004) The RIB trial. Clinical Oncology , 16 (7) 445 - 446.

Hoskin, PJ and Decanha, SM and P, G-J and R, (2004) High dose rate afterloading intraluminal brachytherapy for advanced inoperable rectal carcinoma. Radiotherapy and Oncology , 73 195 - 198.

Hoskin, PJ and Sibtain, A and Daley, FM and Saunders, MI and Wilson, GD (2004) The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma. Radiotherapy and Oncology , 72 (2) 159 - 168.

Howie, AJ (2004) Defining the role of pathology services in the diagnosis and staging of renal cell carcinoma. In: Aitchison, M and Oliver, RTD and Miles, A, (eds.) The Effective Management of Renal Cell Carcinoma. (49 - 53). Aesculapius Medical Press: London.

Howie, AJ and Adu, D (2004) Different meanings of 'glomerular tip lesion'. Kidney International , 66 1716 - ?.

Howie, AJ and Ferreira, MAS and Lipkin, GW and Adu, D (2004) Measurement of chronic damage in the donor kidney and graft survival. Transplantation , 77 1058 - 1065. 10.1097/01.TP.0000120177.44144.FF.

Huhalov, A and Chester, KA (2004) Engineered single chain antibody fragments for radioimmunotherapy. Q J Nucl Med Mol Imaging , 48 (4) 279 - 288.

Huhalov, A and Graff, C and Wittrup, KD and Tolner, B and Pedley, RB and Vervecken, W and Contreras, R and Begent, RHJ and Chester, KA (2004) HSAbodies: A new class of engineered antibody-based molecules for targeting cancer. BRITISH JOURNAL OF CANCER , 91 S63 - S63.

Huhalov, A and Spencer, DIR and Chester, KA (2004) A strategy for characterizing antibody/antigen interactions using proteinchip arrays. In: Conn, PM, (ed.) Handbook of proteomic methods. (117 - 128). Humana Press: New Jersey.

I

Irshad, S and Pedley, RB and Anderson, J and Latchman, DS and Budhram-Mahadeo, V (2004) The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. J BIOL CHEM , 279 (20) 21617 - 21627. 10.1074/jbc.M312506200.
An open access publication

J

Jia, L and Spanswick, VJ and Reid, JM and Kuffel, M and Buhrow, SA and Ames, MM and Hartley, JA and Thurston, DE and Tomaszewski, JE (2004) Use of the comet assay as a surrogate biomarker for the in vivo measurement of DNA damage to lymphocytes. Proceedings of the American Association for Cancer Research , 45 1969 - ?.

K

Kakkar, AK and Bundred, N and Carpenter, R and Makris, A and Merriman, H and Walker, ID (2004) Venous thromboembolism in cancer patients. Guidelines. EGUIDELINES , 23 311 - 314.

Kiakos, K and Hartley, JA and Price, C and Lingerfelt, B and Handl, H and Lee, M (2004) Design, synthesis and DNA alkylation specificity of novel achiral seco-CI-polyamide hairpin conjugates. Proceedings of the American Association for Cancer Research , 45 3091 - ?.

Kiakos, K and Mchugh, PJ and Hartley, JA and Sato, K and Summerville, K and C, L and M, (2004) Design, synthesis and biological evaluation of AS-I-145, a novel achiral amino seco-CBI. Proceedings of the American Association for Cancer Research , 45 3998 - ?.

Kristeleit, RS and Stimson, L and Workman, P and Aherne, G (2004) Histone modification enzymes: novel targets for cancer drugs. Expert Opinion on Emerging Drugs , 9 (1)

Kupchinsky, S and Centioni, S and Howard, T and Trzupek, J and Roller, S and Carnahan, V and Townes, H and Purnell, B and Price, C and Handl, H and Summerville, K and Johnson, K and Toth, J and Hudson, S and Kiakos, K and Hartley, JA and Lee, M (2004) A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties. BIOORGAN MED CHEM , 12 (23) 6221 - 6236.

L

Lacy, ER and Nguyen, B and Le, M and Cox, KK and O'Hare, C and Hartley, JA and Lee, M and Wilson, WD (2004) Energetic basis for selective recognition of T center dot G mismatched base pairs in DNA by imidazole-rich polyamides. NUCLEIC ACIDS RES , 32 (6) 2000 - 2007. 10.1093/nar/gkh515.
An open access publication

Landreau, CAS and LePla, RC and Shipman, M and Slawin, AMZ and Hartley, JA (2004) Delineating noncovalent interactions between the azinomycins and double-stranded DNA: Importance of the naphthalene substitution pattern on interstrand cross-linking efficiency. ORG LETT , 6 (20) 3505 - 3507. 10.1021/ol048653y.

Lankester, KJ and Maxwell, RJ and Pedley, RB and Hill, SA and Rustin, GJS and Tozer, GM (2004) Acute anti-vascular effects of combretastatin A4 phosphate (CA-4-P) on the SW1222 tumour as measured by dynamic contrast enhanced (DCE)-MRI. BRITISH JOURNAL OF CANCER , 91 S16 - S16.

Le Pla, RC and Landreau, CAS and Shipman, M and Slawin, AMZ and Hartley, JA (2004) The role of the naphthoate moiety and its substituents upon the efficiency of DNA interstrand cross-linking by the azinomycins. Mutagenesis , 19 (6) 51 - ?.

Litchfield, TM and Gilchrist, S and Sunderland, R and Folkard, M and Short, S and Prise, K (2004) A three dimensional tissue culture model for microbeam studies. In: Proc Society for neuroscience 34th annual meeting, San Diego. (pp. P 462.4 - ?).

Liu, WM and Strauss, SJ and Chaplin, T and Shahin, S and Propper, DJ and Young, BD and Joel, SP and Malpas, JS (2004) s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line. Hematol J , 5 , Article 3.

M

Makris, A (2004) Critical commentary of: HER-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer. Women's Oncology Review , 4 277 - 278.

Makris, A (2004) Critical commentary of: Quantitative DNA fingerprinting may distinguish new primary breast cancer from disease recurrence. Women's Oncology Review , 4 213 - 214.

Makris, A and Glynne-Jones, R and Sebag-Montefiore, D and Samuel, L and Myint, S and Levine, E and Martin, A and Dixon, J (2004) Compliance to chemotherapy with oxaliplatin and 5fluorouracil in patients with advanced rectal cancer who rave received prior high-dose pelvic radiotherapy. British Journal of Cancer , 91 S34 - S34.

Mayer, A and Francis, R and Sharma, SK and Sully, C and Parker, S and Tolner, B and Griffin, N and Germain, M and Beckett, P and Tolner, B and Boxer, G and Green, A and Chester, KA and Begent, RHJ (2004) A phase I/II trial of antibody directed enzyme prodrug therapy (ADEPT) with MFECP1 and ZD2767P. British Journal of Cancer , 91 S8 - S8.

Mayer, A and Sharma, SK and Tolner, B and Minton, NP and Purdy, D and Amlot, P and Tharakan, G and Begent, RH and Chester, KA (2004) Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT). Br J Cancer , 90 (12) 2402 - 2410. 10.1038/sj.bjc.6601888.

Mayer, A and Sharma, SK and Tolner, B and Minton, NP and Purdy, D and Amlot, P and Tharakan, G and Begent, RHJ and Chester, KA (2004) Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT). BRIT J CANCER , 90 (12) 2402 - 2410. 10.1038/sj.bjc.6601888.

McGurk, CJ and Cummings, M and Hartley, JA and Masters, JR (2004) Translational regulation of ERCC1 in human cancer cell lines. Proceedings of the American Association for Cancer Research , 45 2631 - ?.

Mchugh, PJ and Hartley, JA (2004) Repair of DNA interstrand crosslinks Produced by Cancer Chemotherapeutic Drugs. In: Panasci, LC and Alaoui-Jamali, MA, (eds.) DNA Repair in Cancer Therapy. (31 - 49). Humana Press: Totowa. NJ.

McMeish, I and Kanfer, EJ and Haynes, R and Giles, C and Harland, SJ and Driver, D and Rustin, GJS and Newlands, ES and Seckl, MJ (2004) Paclitaxel-containing high-dose chemotherapy for relapsed or refractory testicular germ cell tumours. British Journal of Cancer , 90 (6) 1169 - 1175.

McTiernan, A and Whelan, JS (2004) A Phase II Study of Docetaxel for the Treatment of Recurrent Osteosarcoma. Sarcoma , 8 (2-3) 71 - 76. 10.1080/13577140410001711764.
An open access publication

Medzihradszky, KF and Spencer, DIR and Sharma, SK and Bhatia, J and Pedley, RB and Read, DA and Begent, RHJ and Chester, KA (2004) Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein. GLYCOBIOLOGY , 14 (1) 27 - 37. 10.1093/glycob/cwh001.

Moroncini, G and Kanu, N and Solforosi, L and Abalos, G and Telling, GC and Head, M and Ironside, J and Brockes, JP and Burton, DR and Williamson, RA (2004) Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc. P NATL ACAD SCI USA , 101 (28) 10404 - 10409. 10.1073/pnas.0403522101.

N

Novak-Hofer, I and Waibel, R and Zimmermann, K and Schibli, R and Grünberg, and J, and Chester, and K, A and Murray, and A, and Lo, and B, K and Perkins, and A, C and Schubiger, and P, A (2004) Radiometal labeling of antibodies and antibody fragments for imaging and therapy. In: Methods Mol Biol. (481 - 494). Humana Press

O

O'Donnell, A and Judson, I and Dowsett, M and Raynaud, F and Dearnaley, D and Mason, M and Harland, S and Robbins, A and Halbert, G and Nutley, B and Jarman, M (2004) Hormonal impact of the 17 alpha-hydroxylase/C-17,C-20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancer , 90 (12) 2317 - 2325.

P

Parker, LL and Lacy, SM and Farrugia, LJ and Evans, C and Robins, DJ and O'Hare, CC and Hartley, JA and Jaffar, M and Stratford, IJ (2004) A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs. J MED CHEM , 47 (23) 5683 - 5689. 10.1021/jm0449866w.

Pedley, RB and Sharma, SK and Hawkins, RE and Chester, KA (2004) Antibody-directed enzyme-prodrug therapy. In: UNSPECIFIED (491 - 514).

Pedley, RB and Sharma, SK and Hawkins, RE and Chester, KA (2004) Antibody-directed Enzyme Prodrug Therapy. In: Springer, CJ, (ed.) Suicide Gene Therapy: Methods and Protocols for Cancer. (491 - 514). Humana Press: Totowa, New Yersey.

Pereira, JJ and Meyer, T and Docherty, SE and Reid, HH and Marshall, J and Thompson, EW and Rossjohn, J and Price, JT (2004) Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alpha v beta 3 negatively modulates IGF- I-mediated migration and tumor growth. Cancer Research , 64 (3) 977 - 984.

Pors, K and Paniwnyk, Z and Ruparelia, KC and Teesdale-Spittle, PH and Hartley, JA and Kelland, LR and Patterson, LH (2004) Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor. J MED CHEM , 47 (7) 1856 - 1859. 10.1021/jm031070u.

R

Reed, JR and Vukmanovic-Stejic, M and Fletcher, JM and Soares, MVD and Cook, JE and Orteu, CH and Jackson, SE and Birch, KE and Foster, GR and Salmon, M and Beverley, PCL and Rustin, MHA and Akbar, AN (2004) Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J EXP MED , 199 (10) 1433 - 1443. 10.1084/jem.20040178.

S

Sartor, O and Reid, RH and Hoskin, PJ and Quick, DP and Ell, PJ and Coleman, RE and Kotler, JA and Freeman, LM and Olivier, P and Quadrament 424Sm10-11 Study Grp, (2004) Samarium-153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer. UROLOGY , 63 (5) 940 - 945. 10.1016/j.urology.2004.01.034.

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Whelan, J (2004) Late Effects of Childhood Cancer. Lancet Oncology

Whelan, JS and McTiernan, A (2004) for the London Bone and Soft Tissue Tumour Service. A prospective study of pre-operative chemotherapy with single agent ifosfamide for malignant fibrous histiocytoma of bone. Sarcoma , 8 77 - 82.
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