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Number of items: 69.

A

Abel, U and Deichmann, A and Bartholomae, C and Schwarzwaelder, K and Glimm, H and Howe, S and Thrasher, A and Garrigue, A and Hacein-Bey-Abina, S and Cavazzana-Calvo, M and Fischer, A and Jaeger, D and von Kalle, C and Schmidt, M (2007) Real-Time Definition of Non-Randomness in the Distribution of Genomic Events. PLOS ONE , 2 (6) , Article e570. 10.1371/journal.pone.0000570.
An open access publication. A version is also available from UCL Discovery.
 file

Alexander, BL and Ali, RR and Alton, EW and Bainbridge, JW and Braun, S and Cheng, SH and Flotte, TR and Gaspar, HB and Grez, M and Griesenbach, U and Kaplitt, MG and Ott, MG and Seger, R and Simons, M and Thrasher, AJ and Thrasher, AZ and Ylä-Herttuala, S (2007) Progress and prospects: gene therapy clinical trials (part 1). Gene Ther , 14 (20) 1439 - 1447. 10.1038/sj.gt.3303001.

Alexander, BL and Ali, RR and Alton, EWFW and Bainbridge, JW and Braun, S and Cheng, SH and Flotte, TR and Gaspar, HB and Grez, M and Griesenbach, U and Kaplitt, MG and Ott, MG and Seger, R and Simons, M and Thrasher, AJ and Thrasher, AZ and Herttuala, SY (2007) Progress and prospects: gene therapy clinical trials (part 1) (vol 14, pg 1439, 2007). GENE THER , 14 (24) 1754 - 1754. 10.1038/sj.gt.3303075.

Apolonia, L and Waddington, S and Fernandes, C and Ward, N and Bouma, G and Thrasher, A and Collins, MK and Philpott, N (2007) Long-term expression from non-integrating lentiviral vectors in muscle. In: HUMAN GENE THERAPY. (pp. 1037 - 1037). MARY ANN LIEBERT INC

Apolonia, L and Waddington, SN and Fernandes, C and Ward, NJ and Bouma, G and Blundell, MP and Thrasher, AJ and Collins, MK and Philpott, NJ (2007) Stable gene transfer to muscle using non-integrating lentiviral vectors. MOL THER , 15 (11) 1947 - 1954. 10.1038/sj.mt.6300281.

B

Bacchelli, C and Buckridge, S and Thrasher, AJ and Gaspar, HB (2007) Translational mini-review series on immunodeficiency: Molecular defects in common variable immunodeficiency. CLIN EXP IMMUNOL , 149 (3) 401 - 409.

Bacchelli, C and Buckridge, S and Thrasher, AJ and Gaspar, HB (2007) Translational Mini-Review Series on Immunodeficiency:Molecular defects in common variable immunodeficiency. Clinical and Experimental Immunology , 149 (3) 401 - 409.

Barker, SE and Grosse, SM and Siapati, EK and Kritz, A and Kinnon, C and Thrasher, AJ and Hart, SL (2007) Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12. BRIT J CANCER , 97 (2) 210 - 217. 10.1038/sj.bjc.6603857.
An open access publication

Barker, SE and Grosse, SM and Siapati, EK and Kritz, A and Kinnon, C and Thrasher, AJ and Hart, SL (2007) Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12. Br J Cancer , 97 (2) 210 - 217.

Bartholomae, C and Balaggan, K and Yanez-Munoz, RJ and Howe, SJ and MacNeil, A and Ali, R and Thrasher, A and von Kalle, C and Schmidt, M (2007) Nearly random lentiviral integration site patterns observed in postmitotic rodent cells. In: HUMAN GENE THERAPY. (pp. 1024 - 1024). MARY ANN LIEBERT INC

Baum, C and Schambach, A and Modlich, U and Thrasher, A (2007) Gene therapy of SCID-X1 | Gentherapie der SCID-X1. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz , 50 (12) 1507 - 1517.

Booth, C and Hershfield, M and Notarangelo, L and Buckley, R and Hoenig, M and Mahlaoui, N and Cavazzana-Calvo, M and Aiuti, A and Gaspar, HB (2007) Management options for adenosine deaminase deficiency; proceedings of the EBMT satellite workshop (Hamburg, March 2006). CLIN IMMUNOL , 123 (2) 139 - 147. 10.1016/j.clin.2006.12.009.

Booth, C and Hershfield, M and Notarangelo, L and Buckley, R and Hoenig, M and Mahlaoui, N and Cavazzana-Calvo, M and Aiuti, A and Gaspar, HB (2007) Management options for adenosine deaminase deficiency; proceedings of the EBMT satellite workshop (Hamburg, March 2006). Clin Immunol , 123 (2) 139 - 147. 10.1016/j.clim.2006.12.009.

Bouma, G and Burns, S and Thrasher, AJ (2007) Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. BLOOD , 110 (13) 4278 - 4284. 10.1182/blood-2007-06-096875.

Boven, LA and Noorbakhsh, F and Bouma, G and van der Zee, R and Vargas, DL and Pardo, C and McArthur, JC and Nottet, HSLM and Power, C (2007) Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation. J NEUROVIROL , 13 (2) 173 - 184. 10.1080/13550280701258399.

Buckland, KF and O'Connor, EC and Coleman, EM and Lira, SA and Lukacs, NW and Hogaboam, CM (2007) Remission of chronic fungal asthma in the absence of CCR8. J ALLERGY CLIN IMMUN , 119 (4) 997 - 1004. 10.1016/j.jaci.2006.12.660.

Buckley, S and Howe, S and Sheard, V and Anson, D and Parsons, D and Thrasher, A and Coutelle, C and Waddington, S and McKay, T (2007) Significant airway transduction after in utero administration of a gp64 pseudotyped lentiviral vector. In: JOURNAL OF GENE MEDICINE. (pp. 526 - 526).

Buckley, SMK and Howe, SJ and Thrasher, A and Baker, AH and Mckay, TR and Coutelle, C and Waddington, S (2007) The route of luciferin administration is a critical determinant of detection of pulmonary and nasal luciferase expression by in vivo bioimaging. In: HUMAN GENE THERAPY. (pp. 1075 - 1075). MARY ANN LIEBERT INC

Burns, S and Hardy, S and Klein, N and Thrasher, A (2007) CD18 is required for normal podosome formation during adhesion and migration of human dendritic cells. In: Medical Research Society Clinical Scientists Day February 07.

C

Cattoglio, C and Facchini, G and Sartori, D and Antonelli, A and Miccio, A and Cassani, B and Schmidt, M and Von Kalle, C and Howe, S and Thrasher, AJ and Aiuti, A and Ferrari, G and Recchia, A and Mavilio, F (2007) Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood , 110 (6) 1770 - 1778.

Charrier, S and Dupré, L and Scaramuzza, S and Jeanson-Leh, L and Blundell, MP and Danos, O and Cattaneo, F and Aiuti, A and Eckenberg, R and Thrasher, AJ and Roncarolo, MG and Galy, A (2007) Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients. Gene Therapy , 14 (5) 415 - 428.

Charrier, S and Dupre, L and Scaramuzza, S and Jeanson-Leh, L and Blundell, MP and Danos, O and Cattaneo, F and Aiuti, A and Eckenberg, R and Thrasher, AJ and Roncarolo, MG and Galy, A (2007) Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients. Gene Ther. , 14 (5) 415 - 428.

Charrier, S and Dupre, L and Scaramuzza, S and Jeanson-Leh, L and Blundell, MP and Danos, O and Cattaneo, F and Aiuti, A and Eckenberg, R and Thrasher, AJ and Roncarolo, MG and Galy, A (2007) Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients. GENE THER , 14 (5) 415 - 428. 10.1038/sj.gt.3302863.

Chatziandreou, E and Gilmour, KC and McNicol, AM and Costabile, M and Sinclair, J and Cubitt, D and Campbell, JDM and Kinnon, C and Qasim, W and Gaspar, HB (2007) Capture and generation of adenovirus specific T cells for adoptive immunotherapy. BRIT J HAEMATOL , 136 (1) 117 - 126. 10.1111/j.1365-2141.2006.06386.x.

Chatziandreou, I and Gilmour, KC and McNicol, AM and Costabile, M and Sinclair, J and Cubitt, D and Campbell, JD and Kinnon, C and Qasim, W and Bobby, GH (2007) Capture and generation of adenovirus specific T cells for adoptive immunotherapy. Br.J.Haematol. , 136 (1) 117 - 126.

Cohen, JM and Cooper, N and Chakrabarti, S and Thomson, K and Samarasinghe, S and Cubitt, D and Lloyd, C and Woolfrey, A and Veys, P and Amrolia, PJ (2007) EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning. Leuk Lymphoma , 48 (2) 256 - 269. 10.1080/10428190601059837.

Cohen, JM and Sebire, NJ and Harvey, J and Gaspar, HB and Cathy, C and Jones, A and Rao, K and Cubitt, D and Amrolia, PJ and Davies, EG and Veys, P (2007) Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation. BLOOD , 110 (6) 2209 - 2214. 10.1182/blood-2006-12-062174.

Cohen, JM and Sebire, NJ and Harvey, J and Gaspar, HB and Cathy, C and Jones, A and Rao, K and Cubitt, D and Amrolia, PJ and Davies, EG and Veys, P (2007) Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation. Blood , 110 (6) 2209 - 2214.

D

Dürrbach, A and Baple, E and Preece, AF and Charpentier, B and Gustafsson, K (2007) Virus recognition by specific natural antibodies and complement results in MHC I cross-presentation. Eur J Immunol , 37 (5) 1254 - 1265. 10.1002/eji.200636129.

Deichmann, A and Hacein-Bey-Abina, S and Schmidt, M and Garrigue, A and Brugman, MH and Hu, J and Glimm, H and Gyapay, G and Prum, B and Fraser, CC and Fischer, N and Schwarzwaelder, K and Siegler, ML and de Ridder, D and Pike-Overzet, K and Howe, SJ and Thrasher, AJ and Wagemaker, G and Abel, U and Staal, FJT and Delabesse, E and Villeval, JL and Aronow, B and Hue, C and Prinz, C and Wissler, M and Klanke, C and Weissenbach, J and Alexander, I and Fischer, A and von Kalle, C and Cavazzana-Calvo, M (2007) Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J CLIN INVEST , 117 (8) 2225 - 2232. 10.1172/JCI31659.

E

Evans, JG and Chavez-Rueda, KA and Eddaoudi, A and Meyer-Bahlburg, A and Rawlings, DJ and Ehrenstein, MR and Mauri, C (2007) Novel suppressive function of transitional 2 B cells in experimental arthritis. J IMMUNOL , 178 (12) 7868 - 7878.

G

Gaspar, B and Thrasher, A (2007) Successful bone marrow gene therapy for severe combined immunodeficiency. Inmunologia , 26 (4) 218 - 219.

Grez, M and Ott, MG and Stein, S and Schultze-Strasser, S and Jauch, A and Burwinkel, B and Preiss, C and Kramer, R and Schwarzwaelder, K and Siler, U and Schmidt, M and von Kalle, C and Thrasher, A and Hoelzer, D and Seger, R (2007) Update on gene therapy for chronic granulomatous disease. In: HUMAN GENE THERAPY. (pp. 959 - 959).

H

Hart, SL and Grosse, S and Tabor, AB and Wong, JB and Elbs, M and Hailes, HC and Mustapa, MFM (2007) Preparation of Peptides and Lipids and their Complexes for the Delivery of Biologically Active Material to Cells. 2007138324.

Himoudi, N and Nabarro, S and Yan, M and Gilmour, K and Thrasher, AJ and Anderson, J (2007) Development of anti-PAX3 immune responses; a target for cancer immunotherapy. Cancer Immunology, Immunotherapy , 56 (9) 1381 - 1395.

Himoudi, N and Nabarro, S and Yan, M and Gilmour, K and Thrasher, AJ and Anderson, J (2007) Development of anti-PAX3 immune responses; a target for cancer immunotherapy. CANCER IMMUNOL IMMUN , 56 (9) 1381 - 1395. 10.1007/s00262-007-0294-3.

K

Karlsson, H and Brewin, J and Kinnon, C and Veys, P and Amrolia, PJ (2007) Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus - An approach for adoptive immunotherapy of multiple pathogens. J IMMUNOTHER , 30 (5) 544 - 556.

Kim, JJ and Thrasher, AJ and Jones, AM and Davies, EG and Cale, CM (2007) Rituximab for the treatment of autoimmune cytopenias in children with immune deficiency. Br J Haematol , 138 (1) 94 - 96. 10.1111/j.1365-2141.2007.06616.x.

King, MA and Eddaoudi, A and Davies, DC (2007) A comparison of three flow cytometry methods for evaluating mitochondrial damage during staurosporine-induced apoptosis in Jurkat cells. CYTOM PART A , 71A (9) 668 - 674. 10.1002/cyto.a.20428.

L

Laurie, KL and Blundell, MP and Baxendale, HE and Howe, SJ and Sinclair, J and Qasim, W and Brunsberg, U and Thrasher, AJ and Holmdahl, R and Gustafsson, K (2007) Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector. GENE THER , 14 (23) 1623 - 1631. 10.1038/sj.gt.3303021.

Leverrier, S and Bergamaschi, D and Ghali, L and Ola, A and Warnes, G and Akgul, B and Blight, K and Garcia-Escudero, R and Penna, A and Eddaoudi, A and Storey, A (2007) Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. APOPTOSIS , 12 (3) 549 - 560. 10.1007/s10495-006-0004-1.

M

Mangat, JS and Rao, K and Kingston, J and Veys, P and Amrolia, P and Burch, M (2007) Early pediatric anthracycline cardiotoxicity: managed by serial heart and bone marrow transplantation. J Heart Lung Transplant , 26 (6) 658 - 660. 10.1016/j.healun.2007.03.014.

Manunta, M (2007) Gene therapy for modulating immune/inflammatory responses. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry , 6 (2) 99 - 99.

Manunta, M and Izzo, L and Duncan, R and Jones, AT (2007) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. J Drug Target , 15 (1) 37 - 50. 10.1080/10611860601010330.

Manunta, M and Tan, PH and George, AJT (2007) Modulation of the immune response by targeting endothelial cells. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry , 6 (2) 169 - 178.

Marshall, CJ and Sinclair, JC and Thrasher, AJ and Kinnon, C (2007) Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro. BRIT J HAEMATOL , 139 (2) 321 - 330. 10.1111/j.1365-2141.2007.06795.x.
An open access publication

Moulding, DA and Blundell, MP and Spiller, DG and White, MRH and Cory, GO and Calle, Y and Kempski, H and Sinclair, J and Ancliff, PJ and Kinnon, C and Jones, GE and Thrasher, AJ (2007) Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J EXP MED , 204 (9) 2213 - 2224. 10.1084/jem.20062324.
An open access publication

Mukherjee, S and Lee, HL and Pacchia, AL and Ron, Y and Dougherty, JP (2007) A HIV-2-based self-inactivating vector for enhanced gene transduction. J.Biotechnol. , 127 (4) 745 - 757.

Mustapa, MFM and Bell, PC and Hurley, CA and Nicol, A and Guenin, E and Bell, PC and Sarkar, S and Writer, MJ and Barker, SE and Wong, JB and Pilkington-Miksa, MA and Papahadjopoulos-Sternberg, B and Shamlou, PA and Hailes, HC and Hart, SL and Zicha, D and Tabor, AB (2007) Biophysical characterization of an integrin-targeted lipopolyplex gene delivery vector. BIOCHEMISTRY-US , 46 (45) 12930 - 12944. 10.1021/bi701014y.

P

Pan-Hammarstrom, Q and Salzer, U and Du, L and Bjorkander, J and Cunningham-Rundles, C and Nelson, DL and Bacchelli, C and Gaspar, HB and Offer, S and Behrens, TW and Grimbacher, B and Hammarstrom, L (2007) Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. NAT GENET , 39 (4) 429 - 430.

Pearce, DJ and Anjos-Afonso, F and Ridler, CM and Eddaoudi, A and Bonnet, D (2007) Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging. STEM CELLS , 25 (4) 828 - 835. 10.1634/stemcells.2006-0405.

Pearce, DJ and Anjos-Afonso, F and Ridler, CM and Eddaoudi, A and Bonnet, D (2007) Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging (vol 25, pg 828, 2007). STEM CELLS , 25 (7) 1852 - 1852.

Philpott, NJ and Thrasher, AJ (2007) Use of nonintegrating lentiviral vectors for gene therapy. HUM GENE THER , 18 (6) 483 - 489. 10.1089/hum.2007.013.

Pike-Overzet, K and de Ridder, D and Weerkamp, F and Baert, MRM and Verstegen, MMA and Brugman, MH and Howe, SJ and Reinders, MJT and Thrasher, AJ and Wagemaker, G and van Dongen, JJM and Staal, FJT (2007) Ectopic retroviral expression of LMO2, but not IL2R gamma, blocks human T-cell development from CD34+cells: implications for leukemogenesis in gene therapy. LEUKEMIA , 21 (4) 754 - 763. 10.1038/sj.leu.2404563.

Pilkington-Miksa, MA and Writer, MJ and Sarkar, S and Meng, QH and Barker, SE and Shamlou, PA and Hailes, HC and Hart, SL and Tabor, AB (2007) Targeting lipopolyplexes using bifunctional peptides incorporating hydrophobic Spacer amino acids: Synthesis, transfection, and biophysical studies. BIOCONJUGATE CHEM , 18 (6) 1800 - 1810. 10.1021/bc0700943.

Q

Qasim, W and Davies, G and Gaspar, B and Cale, C and Amrolia, P and Rao, K and Veys, P (2007) Allogeneic stem cell transplantation for leukocyte adhesion deficiency: 20-year single-centre experience. In: BONE MARROW TRANSPLANTATION. (pp. S75 - S75). NATURE PUBLISHING GROUP

Qasim, W and Gaspar, HB and Thrasher, AJ (2007) Update on clinical gene therapy in childhood. ARCH DIS CHILD , 92 (11) 1028 - 1031. 10.1136/adc.2006.108787.

Qasim, W and Mackey, T and Sinclair, J and Chatziandreou, I and Kinnon, C and Thrasher, AJ and Gaspar, HB (2007) Lentiviral vectors for T-cell suicide gene therapy: Preservation of T-cell effector function after cytokine-mediated transduction. MOL THER , 15 (2) 355 - 360. 10.1038/sj.mt.6300042.

R

Rahim, A and Ward, N and Waddington, S and Elston, K and Cooper, J and Philpott, N and Anderson, P and Thrasher, A and Raivich, G (2007) Cell-specific gene delivery to the adult and in utero CNS using pseudotyped non-integrating lentivirus. In: HUMAN GENE THERAPY. (pp. 1027 - 1027). MARY ANN LIEBERT INC

Ramjaun, AR and Tomlinson, S and Eddaoudi, A and Downward, J (2007) Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. ONCOGENE , 26 (7) 970 - 981. 10.1038/sj.onc.1209852.

Rodrigues, T and Carvalho, A and Carmo, M and Carrondo, MJ and Alves, PM and Cruz, PE (2007) Scaleable purification process for gene therapy retroviral vectors. J Gene Med , 9 (4) 233 - 243. 10.1002/jgm.1021.

S

Salzer, U and Birmelin, J and Bacchelli, C and Witte, T and Buchegger-Podbielski, U and Buckridge, S and Rzepka, R and Gaspar, HB and Thrasher, AJ and Schmidt, RE and Melchers, I and Grimbacher, B (2007) Sequence analysis of TNFRSF13b, encoding TACI, in patients with systemic lupus erythematosus. J CLIN IMMUNOL , 27 (4) 372 - 377. 10.1007/s10875-007-9094-y.

Schwarzwaelder, K and Howe, SJ and Schmidt, M and Brugman, MH and Deichmann, A and Glimm, H and Schmidt, S and Prinz, C and Wissler, M and King, DJS and Zhang, F and Parsley, KL and Gilmour, KC and Sinclair, J and Bayford, J and Peraj, R and Pike-Overzet, K and Staal, FJT and de Ridder, D and Kinnon, C and Abel, U and Wagemaker, G and Gaspar, HB and Thrasher, AJ and von Kalle, C (2007) Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J CLIN INVEST , 117 (8) 2241 - 2249. 10.1172/JCI31661.
An open access version is available from UCL Discovery
 file

Siapati, EK and Bigger, BW and Kashofer, K and Themis, M and Thrasher, AJ and Bonnet, D (2007) Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells. European Journal of Haematology , 78 (4) 303 - 313.

T

Theoharis, S and Manunta, M and Tan, PH (2007) Gene delivery to vascular endothelium using chemical vectors: implications for cardiovascular gene therapy. Expert Opin Biol Ther , 7 (5) 627 - 643. 10.1517/14712598.7.5.627.

V

Vink, C and Gaspar, B and Thrasher, A and Qasim, W (2007) Development of a hybrid lentivirus-transposon gene delivery system. In: HUMAN GENE THERAPY. (pp. 1037 - 1037). MARY ANN LIEBERT INC

W

Ward, N and Apolonia, L and Fernandes, C and Waddington, S and Cochrane, M and Kinnon, C and Thrasher, A and Nathwani, AC and Philpott, N (2007) Non-integrating lentiviral vector pseudotypes for safer gene therapy. In: HUMAN GENE THERAPY. (pp. 1038 - 1038). MARY ANN LIEBERT INC

Z

Zhang, F and Thornhill, S and Howe, SJ and Schambach, A and Gaspar, B and Kinnon, C and Antoniou, M and Thrasher, A (2007) A novel UCOE promoter provides reproducible and stable transgene expression. In: HUMAN GENE THERAPY. (pp. 990 - 990). MARY ANN LIEBERT INC

Zhang, F and Thornhill, SI and Howe, SJ and Ulaganathan, M and Scharnbach, A and Sinclair, J and Kinnon, C and Gaspar, HB and Antoniou, M and Thrasher, AJ (2007) Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. BLOOD , 110 (5) 1448 - 1457. 10.1182/blood-2006-12-060814.
An open access publication

This list was generated on Wed Jun 12 10:08:23 2013 BST.