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Number of items: 82.

A

Allen, J; Fish, PV; Jeffrey, P; (2011) New perspectives on transporters in drug discovery and development: ADME and beyond - Highlights from the Society for Medicines Research Symposium, held on June 23, 2011 at the Millennium Gloucester Hotel & Conference Centre, London, UK. Drugs of the Future , 36 (10) 793 - 799. 10.1358/dof.2011.36.10.1691063.

Allenmark, S; Grainger, RS; Olsson, S; Patel, B; (2011) Resolution and Determination of the Absolute Configuration of the Enantiomers of a trans-α-Disulfoxide. European Journal of Organic Chemistry , 2011 (22) 4089 - 4092. 10.1002/ejoc.201100419.

Andrade-Cetto, A; Heinrich, M; (2011) From the field into the lab: Useful approaches to selecting species based on local knowledge. Frontiers in Pharmacology , APR 10.3389/fphar.2011.00020. Gold open access

Andrews, MD; Fish, PV; Blagg, J; Brabham, TK; Brennan, PE; Bridgeland, A; ... Whitlock, GA; + view all (2011) Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett , 21 (9) 2715 - 2720. 10.1016/j.bmcl.2010.11.120.

B

Balasubramanian, S; Hurley, LH; Neidle, S; (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov , 10 (4) 261 - 275. 10.1038/nrd3428.

Bogin, B; Thompson, JL; Harper, D; Merrell, J; Chowdhury, J; Meier, P; ... Garaj, V; + view all (2011) Intergenerational and transnational correlates of health for Bangladeshi adult daughters and their mothers: Project MINA. In: AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY. (pp. 93 - 93).

Booker, AJ; Zloh, M; Said, M; Suter, A; Heinrich, M; (2011) Metabolomic profiling of saw palmetto products using proton-NMR spectroscopy and multi-variate analysis. In: PLANTA MEDICA. (pp. 1249 - 1249).

Brickley, K; Pozo, K; Stephenson, FA; (2011) N-acetylglucosamine transferase is an integral component of a kinesin-directed mitochondrial trafficking complex. Biochim Biophys Acta , 1813 (1) 269 - 281. 10.1016/j.bbamcr.2010.10.011.

Brickley, K; Stephenson, FA; (2011) Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons. J Biol Chem , 286 (20) 18079 - 18092. 10.1074/jbc.M111.236018. Gold open access

Brucoli, F; Hawkins, RM; James, CH; Wells, G; Jenkins, TC; Ellis, T; ... Thurston, DE; + view all (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. BIOORG MED CHEM LETT , 21 (12) 3780 - 3783. 10.1016/j.bmcl.2011.04.054.

Buanz, ABM; Parkinson, GN; Gaisford, S; (2011) Characterization of Carbamazepine-Nicatinamide Cocrystal Polymorphs with Rapid Heating DSC and XRPD. CRYSTAL GROWTH & DESIGN , 11 (4) 1177 - 1181. 10.1021/cg101377u.

C

Campbell, NH; Smith, DL; Reszka, AP; Neidle, S; O'Hagan, D; (2011) Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem , 9 (5) 1328 - 1331. 10.1039/c0ob00886a.

Casagrande, V; Salvati, E; Alvino, A; Bianco, A; Ciammaichella, A; D'Angelo, C; ... Biroccio, A; + view all (2011) N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. J Med Chem , 54 (5) 1140 - 1156. 10.1021/jm1013665.

Casselman, I; Heinrich, M; (2011) Novel use patterns of Salvia divinorum: unobtrusive observation using YouTube™. J Ethnopharmacol , 138 (3) 662 - 667. 10.1016/j.jep.2011.07.065.

Collie, GW; Parkinson, GN; (2011) The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem Soc Rev , 40 (12) 5867 - 5892. 10.1039/c1cs15067g.

Collie, GW; Sparapani, S; Parkinson, GN; Neidle, S; (2011) Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc , 133 (8) 2721 - 2728. 10.1021/ja109767y.

F

Firdous, N; Gibbons, S; Modell, B; (2011) Falling prevalence of beta-thalassaemia and eradication of malaria in the Maldives. Journal of Community Genetics , 2 (3) 173 - 189. 10.1007/s12687-011-0054-0.

Florian, WM; Whitlock, GA; Fish, PV; Stobie, A; Fray, MJ; (2011) Serotonin/Noradrenaline reuptake inhibitors: A case history in the challenges of multipharmacology and CNS drug discovery. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

G

Garvey, MI; Rahman, MM; Gibbons, S; Piddock, LJV; (2011) Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS , 37 (2) 145 - 151. 10.1016/j.ijantimicag.2010.10.027.

Gibbons, S; (2011) Novel and Emerging Drugs: A Chemical Overview for the Toxicologist. CLINICAL TOXICOLOGY , 49 (3) 198 - 198.

Giovannini, P; Reyes-García, V; Waldstein, A; Heinrich, M; (2011) Do pharmaceuticals displace local knowledge and use of medicinal plants? Estimates from a cross-sectional study in a rural indigenous community, Mexico. Soc Sci Med , 72 (6) 928 - 936. 10.1016/j.socscimed.2011.01.007.

Good, JA; Skoufias, DA; Kozielski, F; (2011) Elucidating the functionality of kinesins: an overview of small molecule inhibitors. Semin Cell Dev Biol , 22 (9) 935 - 945. 10.1016/j.semcdb.2011.09.023.

Grainger, RS; Patel, B; Kariuki, BM; Male, L; Spencer, N; (2011) Sulfur monoxide transfer from peri-substituted trisulfide-2-oxides to dienes: substituent effects, mechanistic studies and application in thiophene synthesis. J Am Chem Soc , 133 (15) 5843 - 5852. 10.1021/ja108865w.

Guimaraes, AMR; Fuente, M; Stapleton, P; Ji, X; Oliyide, AO; Osbourn, A; ... Yang, M; + view all (2011) Glycosylation enhances selectivity of novobiocin and alters antibacterial mechanism. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Guimaraes, AMR; Fuente, MDL; Stapleton, PD; Ji, X; Oliyide, AO; Osbourn, A; ... Yang, M; + view all (2011) Abstract: Glycosylation enhances selectivity of novobiocin and alters antibacterial mechanism. Abstract of Papers of the American Chemical Society , 241 (132-CARB)

Gunaratnam, M; de la Fuente, M; Hampel, SM; Todd, AK; Reszka, AP; Schätzlein, A; Neidle, S; (2011) Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg Med Chem , 19 (23) 7151 - 7157. 10.1016/j.bmc.2011.09.055.

Guzman, JD; Wube, A; Evangelopoulos, D; Gupta, A; Hufner, A; Basavannacharya, C; ... Bhakta, S; + view all (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J ANTIMICROB CHEMOTH , 66 (8) 1766 - 1772. 10.1093/jac/dkr203.

H

Haider, S; Joseph, CG; Neidle, S; Fierke, CA; Fuchter, MJ; (2011) On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett , 21 (7) 2129 - 2132. 10.1016/j.bmcl.2011.01.128.

Haider, SM; Autiero, I; Neidle, S; (2011) Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie , 93 (8) 1275 - 1279. 10.1016/j.biochi.2011.05.014.

Haider, SM; Neidle, S; Parkinson, GN; (2011) A structural analysis of G-quadruplex/ligand interactions. Biochimie , 93 (8) 1239 - 1251. 10.1016/j.biochi.2011.05.012.

Hancock, R; Bertrand, H; Naz, S; Tsujita, T; Hayes, J; Wells, G; (2011) Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction. In: AACR Meeting Abstracts. (pp. 828 - ?).

Heinrich, M; (2011) From Belizean Dioscorea to seaweeds - The many journeys of Prof. Gerry (Gerald) Blunden. Natural Product Communications , 6 (5)

Heinrich, M; Dhanji, T; Casselman, I; (2011) Acai (Euterpe oleracea Mart.)-A phytochemical and pharmacological assessment of the species' health claims. PHYTOCHEMISTRY LETTERS , 4 (1) 10 - 21. 10.1016/j.phytol.2010.11.005.

Hemingway, CJ; Munday, M; (2011) The lipid-lowering agent gemfibrozil inhibits fatty acid esterification. Journal of Pharmacy and Pharmacology , 50 (S9) 10.1111/j.2042-7158.1998.tb02408.x.

I

Ioannou, E; Quesada, A; Rahman, MM; Gibbons, S; Vagias, C; Roussis, V; (2011) Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. J Nat Prod , 74 (2) 213 - 222. 10.1021/np1006586.

K

Kaan, HY; Hackney, DD; Kozielski, F; (2011) The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition. Science , 333 (6044) 883 - 885. 10.1126/science.1204824.

Kaan, HY; Weiss, J; Menger, D; Ulaganathan, V; Tkocz, K; Laggner, C; ... Kozielski, F; + view all (2011) Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. J Med Chem , 54 (6) 1576 - 1586. 10.1021/jm100991m.

König, J; Wyllie, S; Wyatt, PG; Fairlamb, AH; Wells, G; Stevens, MF; (2011) Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. Journal of Biological Chemistry , 286 (10) 8523 - 8533. 10.1074/jbc.M110.214833. Gold open access

Kozielski, F; Riaz, T; DeBonis, S; Koehler, CJ; Kroening, M; Panse, I; ... Thiede, B; + view all (2011) Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino Acids , 41 (2) 363 - 385. 10.1007/s00726-010-0649-5.

L

Laird, EG; Fish, PV; (2011) Evaluation of the relative inhibition of intracellular and extracellular procollagen C-proteinase (PCP) activity in tendon explants by synthetic PCP inhibitors (PCPi). In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. (pp. A12 - A13).

Lalatsa, A; Schätzlein, AG; Uchegbu, IF; (2011) Drug delivery across the blood brain barrier. In: Murray Moo-Young, M and Butler, M and Webb, C and Moreira, A and Grodzinski, B and Cui, Z, (eds.) Comprehensive Biotechnology. (657 - 668). Elsevier: Amsterdam.

Lardos, A; Prieto-Garcia, J; Heinrich, M; (2011) Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach. Front Pharmacol , 2 , Article 32. 10.3389/fphar.2011.00032. Green and gold open access
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Liu, Y; Kumar, A; Depauw, S; Nhili, R; David-Cordonnier, MH; Lee, MP; ... Wilson, WD; + view all (2011) Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc , 133 (26) 10171 - 10183. 10.1021/ja202006u.

Lonetti, A; Szijgyarto, Z; Bosch, D; Loss, O; Azevedo, C; Saiardi, A; (2011) Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases. J Biol Chem , 286 (37) 31966 - 31974. 10.1074/jbc.M111.266320.

Loss, O; Azevedo, C; Szijgyarto, Z; Bosch, D; Saiardi, A; (2011) Preparation of quality inositol pyrophosphates. J Vis Exp (55) e3027 - ?. 10.3791/3027.

Lyngberg, L; Healy, J; Bartlett, W; Miller, S; Conway, SJ; Booth, IR; Rasmussen, T; (2011) KefF, the Regulatory Subunit of the Potassium Efflux System KefC, Shows Quinone Oxidoreductase Activity. Journal of Bacteriology , 193 (18) 4925 - 4932. 10.1128/JB.05272-11.

M

Mamone, L; Di Venosa, G; Valla, JJ; Rodriguez, L; Gandara, L; Batlle, A; ... Casas, A; + view all (2011) CYTOTOXIC EFFECTS OF ARGENTINEAN PLANT EXTRACTS ON TUMOUR AND NORMAL CELL LINES. CELLULAR AND MOLECULAR BIOLOGY , 57 1487 - 1499. 10.1170/171.

Maree, JE; Viljoen, AM; Gibbons, S; (2011) The use of metabolomics for the discovery of antimicrobial biomarkers from Plectranthus species indigenous to southern Africa. In: PLANTA MEDICA. (pp. 1455 - 1455).

Mazza, M; Gaisford, S; Uchegbu, IF; McCarthy, D; Schatzlein, AG; (2011) Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating. In: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. (pp. 650 - 653).

Mazza, M; Schatzlein, A; Uchegbu, I; Gaisford, D; McCarthy, D; (2011) Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating. In: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. (pp. 650 - 653).

Michl, J; Modarai, M; Edwards, S; Heinrich, M; (2011) Metabolomic analysis of Ranunculus spp. as potential agents involved in the etiology of equine grass sickness. J Agric Food Chem , 59 (18) 10388 - 10393. 10.1021/jf201430k.

Michl, J; Simmonds, M; Ingrouille, M; Heinrich, M; (2011) Toxicological risk assessment of Aristolochia species. In: PLANTA MEDICA. (pp. 1236 - 1237).

Modarai, M; Silva, E; Suter, A; Heinrich, M; Kortenkamp, A; (2011) Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression. Evid Based Complement Alternat Med , 2011 213021 - ?. 10.1093/ecam/nep174. Gold open access

Modarai, M; Suter, A; Kortenkamp, A; Heinrich, M; (2011) The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. J Pharm Pharmacol , 63 (3) 429 - 438. 10.1111/j.2042-7158.2010.01235.x.

Munday, M; Hemingway, CJ; (2011) The effect of the lipid-lowering agent gemfibrozil on glucose handling. Journal of Pharmacy and Pharmacology , 50 (S9) 10.1111/j.2042-7158.1998.tb02409.x.

N

Nielsen, MM; Suits, MDL; Yang, M; Barry, CS; Martinez-Fleites, C; Tailford, LE; ... Davies, GJ; + view all (2011) Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase. JOURNAL OF BIOLOGICAL CHEMISTRY , 286 (17) 15155 - 15164. 10.1074/jbc.M110.199844. Gold open access

Nordin, NI; D'acquisto, F; Gibbons, S; Perrett, D; Mageed, RA; (2011) Potent anti-inflammatory compounds identified in Zingiber officinale Roscoe var. rubrum Theilade: Mechanisms of action in psoriasis. In: PLANTA MEDICA. (pp. 1422 - 1423).

O

Obolskiy, D; Pischel, I; Feistel, B; Glotov, N; Heinrich, M; (2011) Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. J Agric Food Chem , 59 (21) 11367 - 11384. 10.1021/jf202277w. Green open access
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P

Parkinson, G; Wilson, C; Gunasekera, A; Ebright, YW; Ebright, RH; Berman, HM; (2011) Erratum: Structure of the CAP-DNA complex at 2.5 Å resolution: A complete picture of the protein-DNA Interface (Journal of Molecular Biology (1996) 260:3 (395-408)). Journal of Molecular Biology , 414 (1) 163 - 163. 10.1016/j.jmb.2011.10.002.

Patel, B; Carlisle, J; Bottle, SE; Hanson, GR; Kariuki, BM; Male, L; ... Grainger, RS; + view all (2011) In search of a new class of stable nitroxide: synthesis and reactivity of a peri-substituted N,N-bissulfonylhydroxylamine. Org Biomol Chem , 9 (7) 2336 - 2344. 10.1039/c0ob00976h.

Patel, SM; de la Fuente, M; Ke, S; Guimarães, AM; Oliyide, AO; Ji, X; ... Yang, M; + view all (2011) High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity. Chem Commun (Camb) , 47 (38) 10569 - 10571. 10.1039/c1cc13552j.

Pereira, I; Swain, A; Turton, J; Scudamore, CL; Maguire, D; Smyth, R; ... York, M; + view all (2011) Urinary biomarkers of renal injury in the hexachloro-1:3-butadiene treated male Hanover Wistar rat; a dose-response study at low dose levels. TOXICOLOGY , 290 (2-3) 138 - 139. 10.1016/j.tox.2011.09.066.

Peschel, W; Kump, A; Prieto, JM; (2011) Effects of 20-hydroxyecdysone, Leuzea carthamoides extracts, dexamethasone and their combinations on the NF-κB activation in HeLa cells. J Pharm Pharmacol , 63 (11) 1483 - 1495. 10.1111/j.2042-7158.2011.01349.x.

Petraccone, L; Fotticchia, I; Cummaro, A; Pagano, B; Ginnari-Satriani, L; Haider, S; ... Giancola, C; + view all (2011) The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies. Biochimie , 93 (8) 1318 - 1327. 10.1016/j.biochi.2011.05.017.

Petralia, RS; Wang, YX; Hua, F; Yi, Z; Zhou, A; Ge, L; ... Wenthold, RJ; + view all (2011) ORGANIZATION OF NMDA RECEPTORS AT EXTRASYNAPTIC LOCATIONS (vol 167, pg 68, 2010). NEUROSCIENCE , 176 472 - 472. 10.1016/j.neuroscience.2010.12.020.

Petralia, RS; Wang, YX; Hua, F; Yi, Z; Zhou, A; Ge, L; ... Stephenson, FA; + view all (2011) Corrigendum to "organization of NMDA receptors at extrasynaptic locations". [Neuroscience 167 (2010) 68-87]. Neuroscience , 176 472 - 472. 10.1016/j.neuroscience.2010.12.020.

Prieto, JM; (2011) En busqueda de la calidad. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas , 10 (4) 289 - 291. Gold open access

Prieto, JM; (2011) Looking for quality. BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS , 10 (4) 289 - 291. Gold open access

R

Rahman, KM; James, CH; Bui, TTT; Drake, AF; Thurston, DE; (2011) Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct. Journal of the American Chemical Society , 133 (48) 19376 - 19385. 10.1021/ja205395r.

Rahman, KM; James, CH; Thurston, DE; (2011) Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers. Nucleic Acids Research , 39 (13) 5800 - 5812. 10.1093/nar/gkr122. Green and gold open access
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Rahman, KM; James, CH; Thurston, DE; (2011) Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy. Organic and Biomolecular Chemistry , 9 (5) 1632 - 1641. 10.1039/c0ob00762e.

Rahman, SS; Simovic, I; Gibbons, S; Zloh, M; (2011) In silico screening for antibiotic escort molecules to overcome efflux. J Mol Model , 17 (11) 2863 - 2872. 10.1007/s00894-011-0978-7.

Randall, TS; Moores, C; Stephenson, A; (2011) Binding studies of the TRAK/kinesin-1 trafficking complex. In: MOLECULAR BIOLOGY OF THE CELL.

S

Said, MM; Gibbons, S; Moffat, AC; Zloh, M; (2011) Near-infrared spectroscopy (NIRS) and chemometric analysis of Malaysian and UK paracetamol tablets: a spectral database study. Int J Pharm , 415 (1-2) 102 - 109. 10.1016/j.ijpharm.2011.05.057.

Sil, BC; Cook, KM; Schofield, C; Figg, WD; Hilton, ST; (2011) Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Sil, BC; Hilton, ST; (2011) Diversity from simplicity: A common precursor approach towards natural products. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Siriwatanametanon, N; Heinrich, M; (2011) The Thai medicinal plant Gynura pseudochina var. hispida: chemical composition and in vitro NF-kappaB inhibitory activity. Nat Prod Commun , 6 (5) 627 - 630.

Stephenson, FA; Perkinton, MS; (2011) Receptors NMDA et maladie d?Alzheimer. Alzheimer Actualit�s , 214 8 - 13.

Swain, A; Turton, J; Scudamore, CL; Pereira, I; Viswanathan, N; Smyth, R; ... York, M; + view all (2011) Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of alpha-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression. J APPL TOXICOL , 31 (4) 366 - 377. 10.1002/jat.1624.

T

Thompson, JL; Merrell, J; Bogin, B; Heinrich, M; Meier, P; Garaj, V; (2011) MIGRATION, NUTRITION AND AGEING ACROSS THE LIFECOURSE IN BANGLADESHI FAMILIES: PROJECT MINA. GERONTOLOGIST , 51 345 - 345.

Todd, AK; Neidle, S; (2011) Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Res , 39 (12) 4917 - 4927. 10.1093/nar/gkr104. Green and gold open access
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V

Viladoms, J; Scott, LG; Fedor, MJ; (2011) An Active-Site Guanine Participates in glmS Ribozyme Catalysis in Its Protonated State. Journal of the American Chemical Society , 133 , Article 45. 10.1021/ja207426j.

This list was generated on Sun Jul 20 10:20:21 2014 BST.