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Number of items: 72.
A
| Allen, J and Fish, PV and Jeffrey, P (2011) New perspectives on transporters in drug discovery and development: ADME and beyond - Highlights from the Society for Medicines Research Symposium, held on June 23, 2011 at the Millennium Gloucester Hotel & Conference Centre, London, UK. Drugs of the Future , 36 (10) 793 - 799. |
| Andrade-Cetto, A and Heinrich, M (2011) From the field into the lab: Useful approaches to selecting species based on local knowledge. Frontiers in Pharmacology , APR |
| Andrews, MD and Fish, PV and Blagg, J and Brabham, TK and Brennan, PE and Bridgeland, A and Brown, AD and Bungay, PJ and Conlon, KM and Edmunds, NJ and af Forselles, K and Gibbons, CP and Green, MP and Hanton, G and Holbrook, M and Jessiman, AS and McIntosh, K and McMurray, G and Nichols, CL and Root, JA and Storer, RI and Sutton, MR and Ward, RV and Westbrook, D and Whitlock, GA (2011) Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett , 21 (9) 2715 - 2720. 10.1016/j.bmcl.2010.11.120. |
| Ashiru, DA and Karu, K and Zloh, M and Patel, R and Basit, AW (2011) Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry. Int J Pharm , 414 (1-2) 35 - 41. 10.1016/j.ijpharm.2011.04.061. |
B
| Balasubramanian, S and Hurley, LH and Neidle, S (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov , 10 (4) 261 - 275. 10.1038/nrd3428. |
| Barata, T and Teo, I and Lalwani, S and Simanek, E and Zloh, M and Shaunak, S (2011) Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex. Biomaterials , 32 (33) 8702 - 8711. 10.1016/j.biomaterials.2011.07.085. |
| Barata, TS and Brocchini, S and Teo, I and Shaunak, S and Zloh, M (2011) From sequence to 3D structure of hyperbranched molecules: application to surface modified PAMAM dendrimers. J Mol Model , 17 (11) 2741 - 2749. 10.1007/s00894-011-0966-y. |
| Barata, TS and Shaunak, S and Teo, I and Zloh, M and Brocchini, S (2011) Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers. J Mol Model , 17 (8) 2051 - 2060. 10.1007/s00894-010-0907-1. |
| Barata, TS and Teo, I and Brocchini, S and Zloh, M and Shaunak, S (2011) Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses. PLoS Comput Biol , 7 (6) e1002095 - ?. 10.1371/journal.pcbi.1002095. |
| Bogin, B and Thompson, JL and Harper, D and Merrell, J and Chowdhury, J and Meier, P and Heinrich, M and Garaj, V (2011) Intergenerational and transnational correlates of health for Bangladeshi adult daughters and their mothers: Project MINA. In: AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY. (pp. 93 - 93). |
| Booker, AJ and Zloh, M and Said, M and Suter, A and Heinrich, M (2011) Metabolomic profiling of saw palmetto products using proton-NMR spectroscopy and multi-variate analysis. In: PLANTA MEDICA. (pp. 1249 - 1249). |
| Brickley, K and Pozo, K and Stephenson, FA (2011) N-acetylglucosamine transferase is an integral component of a kinesin-directed mitochondrial trafficking complex. Biochim Biophys Acta , 1813 (1) 269 - 281. 10.1016/j.bbamcr.2010.10.011. |
| Brickley, K and Stephenson, FA (2011) Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons. J Biol Chem , 286 (20) 18079 - 18092. 10.1074/jbc.M111.236018. |
| Brucoli, F and Hawkins, RM and James, CH and Wells, G and Jenkins, TC and Ellis, T and Hartley, JA and Howard, PW and Thurston, DE (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. BIOORG MED CHEM LETT , 21 (12) 3780 - 3783. 10.1016/j.bmcl.2011.04.054. |
| Buanz, ABM and Parkinson, GN and Gaisford, S (2011) Characterization of Carbamazepine-Nicatinamide Cocrystal Polymorphs with Rapid Heating DSC and XRPD. CRYSTAL GROWTH & DESIGN , 11 (4) 1177 - 1181. 10.1021/cg101377u. |
C
| Campbell, NH and Smith, DL and Reszka, AP and Neidle, S and O'Hagan, D (2011) Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem , 9 (5) 1328 - 1331. 10.1039/c0ob00886a. |
| Casagrande, V and Salvati, E and Alvino, A and Bianco, A and Ciammaichella, A and D'Angelo, C and Ginnari-Satriani, L and Serrilli, AM and Iachettini, S and Leonetti, C and Neidle, S and Ortaggi, G and Porru, M and Rizzo, A and Franceschin, M and Biroccio, A (2011) N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. J Med Chem , 54 (5) 1140 - 1156. 10.1021/jm1013665. |
| Casselman, I and Heinrich, M (2011) Novel use patterns of Salvia divinorum: unobtrusive observation using YouTube™. J Ethnopharmacol , 138 (3) 662 - 667. 10.1016/j.jep.2011.07.065. |
| Collie, GW and Parkinson, GN (2011) The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem Soc Rev , 40 (12) 5867 - 5892. 10.1039/c1cs15067g. |
| Collie, GW and Sparapani, S and Parkinson, GN and Neidle, S (2011) Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc , 133 (8) 2721 - 2728. 10.1021/ja109767y. |
F
| Firdous, N and Gibbons, S and Modell, B (2011) Falling prevalence of beta-thalassaemia and eradication of malaria in the Maldives. Journal of Community Genetics , 2 (3) 173 - 189. |
| Florian, WM and Whitlock, GA and Fish, PV and Stobie, A and Fray, MJ (2011) Serotonin/Noradrenaline reuptake inhibitors: A case history in the challenges of multipharmacology and CNS drug discovery. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. |
G
| Garvey, MI and Rahman, MM and Gibbons, S and Piddock, LJV (2011) Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS , 37 (2) 145 - 151. 10.1016/j.ijantimicag.2010.10.027. |
| Gibbons, S (2011) Novel and Emerging Drugs: A Chemical Overview for the Toxicologist. CLINICAL TOXICOLOGY , 49 (3) 198 - 198. |
| Giovannini, P and Reyes-García, V and Waldstein, A and Heinrich, M (2011) Do pharmaceuticals displace local knowledge and use of medicinal plants? Estimates from a cross-sectional study in a rural indigenous community, Mexico. Soc Sci Med , 72 (6) 928 - 936. 10.1016/j.socscimed.2011.01.007. |
| Grainger, RS and Patel, B and Kariuki, BM and Male, L and Spencer, N (2011) Sulfur monoxide transfer from peri-substituted trisulfide-2-oxides to dienes: substituent effects, mechanistic studies and application in thiophene synthesis. J Am Chem Soc , 133 (15) 5843 - 5852. 10.1021/ja108865w. |
| Guimaraes, AMR and Fuente, M and Stapleton, P and Ji, X and Oliyide, AO and Osbourn, A and Pan, Y and Bowles, DJ and Davis, BG and Schatzlein, A and Yang, M (2011) Glycosylation enhances selectivity of novobiocin and alters antibacterial mechanism. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. |
| Guimaraes, AMR and Fuente, MDL and Stapleton, PD and Ji, X and Oliyide, AO and Osbourn, A and Pandit, S and Bowles, DJ and Davis, BG and Schatzlein, AG and Yang, M (2011) Abstract: Glycosylation enhances selectivity of novobiocin and alters antibacterial mechanism. Abstract of Papers of the American Chemical Society , 241 (132-CARB) |
| Gunaratnam, M and de la Fuente, M and Hampel, SM and Todd, AK and Reszka, AP and Schätzlein, A and Neidle, S (2011) Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg Med Chem , 19 (23) 7151 - 7157. 10.1016/j.bmc.2011.09.055. |
| Guzman, JD and Wube, A and Evangelopoulos, D and Gupta, A and Hufner, A and Basavannacharya, C and Rahman, MM and Thomaschitz, C and Bauer, R and McHugh, TD and Nobeli, I and Prieto, JM and Gibbons, S and Bucar, F and Bhakta, S (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J ANTIMICROB CHEMOTH , 66 (8) 1766 - 1772. 10.1093/jac/dkr203. |
H
| Haider, S and Joseph, CG and Neidle, S and Fierke, CA and Fuchter, MJ (2011) On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett , 21 (7) 2129 - 2132. 10.1016/j.bmcl.2011.01.128. |
| Haider, SM and Autiero, I and Neidle, S (2011) Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie , 93 (8) 1275 - 1279. 10.1016/j.biochi.2011.05.014. |
| Haider, SM and Neidle, S and Parkinson, GN (2011) A structural analysis of G-quadruplex/ligand interactions. Biochimie , 93 (8) 1239 - 1251. 10.1016/j.biochi.2011.05.012. |
| Heinrich, M (2011) From Belizean Dioscorea to seaweeds - The many journeys of Prof. Gerry (Gerald) Blunden. Natural Product Communications , 6 (5) |
| Heinrich, M and Dhanji, T and Casselman, I (2011) Acai (Euterpe oleracea Mart.)-A phytochemical and pharmacological assessment of the species' health claims. PHYTOCHEMISTRY LETTERS , 4 (1) 10 - 21. 10.1016/j.phytol.2010.11.005. |
I
| Ioannou, E and Quesada, A and Rahman, MM and Gibbons, S and Vagias, C and Roussis, V (2011) Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. J Nat Prod , 74 (2) 213 - 222. 10.1021/np1006586. |
K
| König, J and Wyllie, S and Wells, G and Stevens, MF and Wyatt, PG and Fairlamb, AH (2011) Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. Journal of Biological Chemistry , 286 (10) 8523 - 8533. |
L
| Laird, EG and Fish, PV (2011) Evaluation of the relative inhibition of intracellular and extracellular procollagen C-proteinase (PCP) activity in tendon explants by synthetic PCP inhibitors (PCPi). In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. (pp. A12 - A13). |
| Lalatsa, A and Schätzlein, AG and Uchegbu, IF (2011) Drug delivery across the blood brain barrier. In: Murray Moo-Young, M and Butler, M and Webb, C and Moreira, A and Grodzinski, B and Cui, Z, (eds.) Comprehensive Biotechnology. (657 - 668). Elsevier: Amsterdam. |
| Lardos, A and Prieto-Garcia, J and Heinrich, M (2011) Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach. Front Pharmacol , 2 , Article 32. 10.3389/fphar.2011.00032. |  |
| Liu, Y and Kumar, A and Depauw, S and Nhili, R and David-Cordonnier, MH and Lee, MP and Ismail, MA and Farahat, AA and Say, M and Chackal-Catoen, S and Batista-Parra, A and Neidle, S and Boykin, DW and Wilson, WD (2011) Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc , 133 (26) 10171 - 10183. 10.1021/ja202006u. |
M
| Mamone, L and Di Venosa, G and Valla, JJ and Rodriguez, L and Gandara, L and Batlle, A and Heinrich, M and Juarranz, A and Sanz-Rodriguez, F and Casas, A (2011) CYTOTOXIC EFFECTS OF ARGENTINEAN PLANT EXTRACTS ON TUMOUR AND NORMAL CELL LINES. CELLULAR AND MOLECULAR BIOLOGY , 57 1487 - 1499. 10.1170/171. |
| Maree, JE and Viljoen, AM and Gibbons, S (2011) The use of metabolomics for the discovery of antimicrobial biomarkers from Plectranthus species indigenous to southern Africa. In: PLANTA MEDICA. (pp. 1455 - 1455). |
| Mazza, M and Gaisford, S and McCarthy, D and Schatzlein, AG and Uchegbu, IF (2011) Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating. In: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. (pp. 650 - 653). |
| Mazza, M and Schatzlein, A and Uchegbu, I and Gaisford, D and McCarthy, D (2011) Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating. In: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. (pp. 650 - 653). |
| Michl, J and Modarai, M and Edwards, S and Heinrich, M (2011) Metabolomic analysis of Ranunculus spp. as potential agents involved in the etiology of equine grass sickness. J Agric Food Chem , 59 (18) 10388 - 10393. 10.1021/jf201430k. |
| Michl, J and Simmonds, M and Ingrouille, M and Heinrich, M (2011) Toxicological risk assessment of Aristolochia species. In: PLANTA MEDICA. (pp. 1236 - 1237). |
| Modarai, M and Silva, E and Suter, A and Heinrich, M and Kortenkamp, A (2011) Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression. Evid Based Complement Alternat Med , 2011 213021 - ?. 10.1093/ecam/nep174. |
| Modarai, M and Suter, A and Kortenkamp, A and Heinrich, M (2011) The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. J Pharm Pharmacol , 63 (3) 429 - 438. 10.1111/j.2042-7158.2010.01235.x. |
| Moorhouse, AD and Spiteri, C and Sharma, P and Zloh, M and Moses, JE (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chem Commun (Camb) , 47 (1) 230 - 232. 10.1039/c0cc01166e. |
N
| Neidle, S (2011) Therapeutic Applications of Quadruplex Nucleic Acids. Academic Press |
| Nielsen, MM and Suits, MDL and Yang, M and Barry, CS and Martinez-Fleites, C and Tailford, LE and Flint, JE and Dumon, C and Davis, BG and Gilbert, HJ and Davies, GJ (2011) Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase. JOURNAL OF BIOLOGICAL CHEMISTRY , 286 (17) 15155 - 15164. 10.1074/jbc.M110.199844. |
| Nordin, NI and D'acquisto, F and Gibbons, S and Perrett, D and Mageed, RA (2011) Potent anti-inflammatory compounds identified in Zingiber officinale Roscoe var. rubrum Theilade: Mechanisms of action in psoriasis. In: PLANTA MEDICA. (pp. 1422 - 1423). |
O
| Obolskiy, D and Pischel, I and Feistel, B and Glotov, N and Heinrich, M (2011) Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. J Agric Food Chem , 59 (21) 11367 - 11384. 10.1021/jf202277w. | |
P
| Parkinson, G and Wilson, C and Gunasekera, A and Ebright, YW and Ebright, RH and Berman, HM (2011) Erratum: Structure of the CAP-DNA complex at 2.5 Å resolution: A complete picture of the protein-DNA Interface (Journal of Molecular Biology (1996) 260:3 (395-408)). Journal of Molecular Biology , 414 (1) 163 - 163. |
| Patel, B and Carlisle, J and Bottle, SE and Hanson, GR and Kariuki, BM and Male, L and McMurtrie, JC and Spencer, N and Grainger, RS (2011) In search of a new class of stable nitroxide: synthesis and reactivity of a peri-substituted N,N-bissulfonylhydroxylamine. Org Biomol Chem , 9 (7) 2336 - 2344. 10.1039/c0ob00976h. |
| Patel, SM and de la Fuente, M and Ke, S and Guimarães, AM and Oliyide, AO and Ji, X and Stapleton, P and Osbourn, A and Pan, Y and Bowles, DJ and Davis, BG and Schatzlein, A and Yang, M (2011) High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity. Chem Commun (Camb) , 47 (38) 10569 - 10571. 10.1039/c1cc13552j. |
| Peschel, W and Kump, A and Prieto, JM (2011) Effects of 20-hydroxyecdysone, Leuzea carthamoides extracts, dexamethasone and their combinations on the NF-κB activation in HeLa cells. J Pharm Pharmacol , 63 (11) 1483 - 1495. 10.1111/j.2042-7158.2011.01349.x. |
| Petraccone, L and Fotticchia, I and Cummaro, A and Pagano, B and Ginnari-Satriani, L and Haider, S and Randazzo, A and Novellino, E and Neidle, S and Giancola, C (2011) The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies. Biochimie , 93 (8) 1318 - 1327. 10.1016/j.biochi.2011.05.017. |
| Prieto, JM (2011) Looking for quality. BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS , 10 (4) 289 - 291. |
| Prieto, JM (2011) Looking for quality | En busqueda de la calidad. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas , 10 (4) 289 - 291. |
R
| Rahman, KM and James, CH and Bui, TTT and Drake, AF and Thurston, DE (2011) Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct. Journal of the American Chemical Society , 133 (48) 19376 - 19385. 10.1021/ja205395r. |
| Rahman, KM and James, CH and Thurston, DE (2011) Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers. Nucleic Acids Research , 39 (13) 5800 - 5812. 10.1093/nar/gkr122. | |
| Rahman, KM and James, CH and Thurston, DE (2011) Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy. Organic and Biomolecular Chemistry , 9 (5) 1632 - 1641. |
| Rahman, SS and Simovic, I and Gibbons, S and Zloh, M (2011) In silico screening for antibiotic escort molecules to overcome efflux. J Mol Model , 17 (11) 2863 - 2872. 10.1007/s00894-011-0978-7. |
S
| Said, MM and Gibbons, S and Moffat, AC and Zloh, M (2011) Near-infrared spectroscopy (NIRS) and chemometric analysis of Malaysian and UK paracetamol tablets: a spectral database study. Int J Pharm , 415 (1-2) 102 - 109. 10.1016/j.ijpharm.2011.05.057. |
| Sil, BC and Cook, KM and Schofield, C and Figg, WD and Hilton, ST (2011) Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. |
| Sil, BC and Hilton, ST (2011) Diversity from simplicity: A common precursor approach towards natural products. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. |
| Siriwatanametanon, N and Heinrich, M (2011) The Thai medicinal plant Gynura pseudochina var. hispida: chemical composition and in vitro NF-kappaB inhibitory activity. Nat Prod Commun , 6 (5) 627 - 630. |
| Stephenson, FA and Perkinton, MS (2011) Receptors NMDA et maladie d?Alzheimer. Alzheimer Actualit�s , 214 8 - 13. |
T
| Thompson, JL and Merrell, J and Bogin, B and Heinrich, M and Meier, P and Garaj, V (2011) MIGRATION, NUTRITION AND AGEING ACROSS THE LIFECOURSE IN BANGLADESHI FAMILIES: PROJECT MINA. GERONTOLOGIST , 51 345 - 345. |
| Todd, AK and Neidle, S (2011) Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Res , 39 (12) 4917 - 4927. 10.1093/nar/gkr104. | |